Evidence map›Paper›PMID 33534004›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Chromosome X aneusomy and androgen receptor gene copy number aberrations in apocrine carcinoma of the breast.

Anna Cremonini, Luca Saragoni, Luca Morandi, Angelo G Corradini, Caterina Ravaioli, Enrico Di Oto, Francesco Limarzi, Alejandro M Sanchez, Maria C Cucchi, Riccardo Masetti and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Anna CremoniniAnatomic Pathology Section, Department of Oncology, Bellaria Hospital, AUSL Bologna, Via Altura 3, 40139, Bologna, Italy.
Luca SaragoniPathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.ORCID https://orcid.org/0000-0002-2137-9596
Luca MorandiDepartment of Biomedical and Neuromotor Sciences, Functional MR Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, University of Bologna, 40139, Bologna, Italy.ORCID https://orcid.org/0000-0002-3810-9760
Angelo G CorradiniAnatomic Pathology Section "M. Malpighi" Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139, Bologna, Italy.
Caterina RavaioliAnatomic Pathology Section "M. Malpighi" Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139, Bologna, Italy.
Enrico Di OtoLaboratory of Molecular Pathology and Anatomic Pathology, S. Orsola Clinical Hospital, Viale Ercolani 4/2, 40138, Bologna, Italy.ORCID https://orcid.org/0000-0002-3330-6386
Francesco LimarziPathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.ORCID https://orcid.org/0000-0002-1367-3525
Alejandro M SanchezMultidisciplinary Breast Center - Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.ORCID https://orcid.org/0000-0002-4840-507X
Maria C CucchiUnit of Breast Surgery, Department of Oncology, Bellaria Hospital, AUSL Bologna, 40139, Bologna, Italy.ORCID https://orcid.org/0000-0003-3197-7570
Riccardo MasettiMultidisciplinary Breast Center - Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.ORCID https://orcid.org/0000-0002-7520-9111
Cecily QuinnDepartment of Histopathology, St. Vincent's University Hospital, Dublin, Ireland.ORCID https://orcid.org/0000-0001-8920-5480
Maria P FoschiniAnatomic Pathology Section, Department of Oncology, Bellaria Hospital, AUSL Bologna, Via Altura 3, 40139, Bologna, Italy. Mariapia.foschini@unibo.it.ORCID http://orcid.org/0000-0001-7079-7260
Ospedale Bellaria · ITAgostino Gemelli University Polyclinic · ITOspedale G.B. Morgagni - L.Pierantoni · ITUniversity of Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITIstituto delle Scienze Neurologiche di Bologna · ITUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression of androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated the genetic changes that are associated with AR immunohistochemical expression in CADs. The present work aims to characterise AR status in CADs. Twenty CAD tumours were studied with immunohistochemistry, in situ fluorescence hybridization and DNA methylation analysis, to evaluate AR expression and its regulator status. All tumours demonstrated high AR immunohistochemical expression, with over 95% of the neoplastic cells showing AR positivity in 19/20 cases. CADs showed AR gene copy loss in a percentage of neoplastic cells ranging from 5 to 84% (mean 48.93%). AR regulator genes, including the MAGE family, UXT and FLNA, presented variable methylation levels, but were mainly hypomethylated and therefore all transcriptionally active. The results of this study indicate that CADs present AR monosomy, paralleled by higher transcriptional activity of the gene with potential to influence response to AR deprivation therapy.

Indexed as

Chromosomes, Human, XDNA Copy Number VariationsGene DosageSex Chromosome AberrationsAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCarcinomaCell DifferentiationDNA MethylationFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansImmunohistochemistryAR protein, humanBiomarkers, TumorReceptors, AndrogenAndrogen receptorCarcinoma with apocrine differentiationDNA methylationTriple negative breast cancerX chromosome

Identifiers

PMID33534004
PMCPMC8364532
OpenAlexW3127306746

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.