ArticleAsian journal of andrology
Influence of sperm morphology on pregnancy outcome and offspring in
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Meta-correlation of Sperm Morphology and DNA Fragmentation Index.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Congenital anomalies observed in children conceived through assisted reproductive technology-a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Intracytoplasmic sperm injection versus conventional in vitro fertilization in infertile couples with normal total sperm count and motility: does sperm morphology matter?Human reproduction (Oxford, England) · 2025Trial
- Influencing factors of live birth in vitrified oocyte donation cycles: A retrospective cohort study.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- SPACA4 regulates the structure and molecular basis of spermatid maturation and ultimately affects sperm quality in mice.Asian journal of andrology · 2026Article
- Influence of Borderline and Pathological Sperm Morphology on Pregnancy Outcomes following Intrauterine Insemination in Pregnant Women: A Retrospective Study.International journal of fertility & sterility · 2026Article
- Comparative machine learning analysis identifies random forest and adaboost as superior models for the evaluation of semen quality and reproductive hormones.Frontiers in reproductive health · 2026Article
- Predictors of elevated sperm DNA fragmentation: a morphology-based approach to semen analysis.Basic and clinical andrology · 2025Article
- Sperm selection for assisted reproductive technology: do we have a winner?Journal of assisted reproduction and genetics · 2025Review
- AMH as a Predictor of Follicle Turnover, Embryo Quality, and Pregnancy Outcomes: A Retrospective Analysis.Biomedicines · 2025Article
- Impact of Male Age and Semen Parameters on Blastocyst Morphology, Beta-HCG Positivity and Pregnancy Viability: A Retrospective Analysis in Frozen Embryo Transfer Cycles.Journal of obstetrics and gynaecology of India · 2025Article
- Mitochondrial morphology in fertile and infertile men: image processing and morphometric analysis of the sperm midpiece.Frontiers in cell and developmental biology · 2025Article
- A narrative review of sperm selection technology for assisted reproduction techniques.Translational andrology and urology · 2024Review
- Can Microfluidics Improve Sperm Quality? A Prospective Functional Study.Biomedicines · 2024Article
- Article
- Article
- Observational
- Sperm morphology value in assisted reproduction: dismantling an enigma and key takeaways for the busy clinician.Therapeutic advances in reproductive healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm morphology was once believed as one of the most predictive indicators of pregnancy outcome in assisted reproductive technology (ART). However, the impact of teratozoospermia on in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes and its offspring remains inconclusive. In order to evaluate the influence of teratozoospermia on pregnancy outcome and newborn status after IVF and ICSI, a retrospective study was conducted. This was a matched case-control study that included 2202 IVF cycles and 2574 ICSI cycles and was conducted at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, China, from June 2013 to June 2018. Patients were divided into two groups based on sperm morphology: teratozoospermia and normal sperm group. The pregnancy outcome and newborn outcome were analyzed. The results indicated that couples with teratozoospermia had a significantly lower optimal embryo rate compared to those with normal sperm morphology in IVF (P = 0.007), while there were no statistically significant differences between the two groups in terms of the fertilization rate, cleavage rate, implantation rate, and pregnancy rate (all P > 0.05). Additionally, teratozoospermia was associated with lower infant birth weight in multiple births after IVF. With regard to ICSI, there was no significant difference in both pregnancy outcome and newborn outcome between the teratozoospermia and normal groups (both P > 0.05). Furthermore, no increase in the risk of birth defects occurred in the teratozoospermia group after IVF/ICSI. Consequently, we believe that teratozoospermia has limited predictive value for pregnancy outcomes in IVF/ICSI, and has little impact on the resulting offspring if multiple pregnancy is avoided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.