ArticleeLife2021
Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- T cell fate is dictated by different antigen-presenting cells in response to dietary versus gut epithelial self-antigen.Immunity · 2026Article
- Metabolic sensor AMPK licenses intestinal CD103Science advances · 2026Article
- Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.Current microbiology · 2026Review
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
- Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells.Discovery immunology · 2026Review
- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Crosstalk between the microbiota and intestinal dendritic cells in IBD.Seminars in immunopathology · 2025Review
- Article
- A wave of Thetis cells imparts tolerance to food antigens early in life.Science (New York, N.Y.) · 2025Article
- Article
- A hierarchy of intestinal antigens instructs the CD4Immunity · 2025Article
- Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes.Cellular & molecular biology letters · 2025Article
- Identification of antigen-presenting cell-T cell interactions driving immune responses to food.Science (New York, N.Y.) · 2025Article
- Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?Trends in immunology · 2025Review
- Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells.Nature communications · 2024Article
- Beneficial Effects of Dietary Fiber in Young Barley Leaf on Gut Microbiota and Immunity in Mice.Molecules (Basel, Switzerland) · 2024Article
- The emerging family of RORγtNature reviews. Immunology · 2024Review
- Regulatory T cells in the face of the intestinal microbiota.Nature reviews. Immunology · 2023Review
- Activation, Amplification, and Ablation as Dynamic Mechanisms of Dendritic Cell Maturation.Biology · 2023Review
- A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice.JCI insight · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Emilie V Russler-GermainDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0002-2036-6697
Jaeu YiDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.
Shannon YoungDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.
Katherine NutschDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.
Harikesh S WongLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States.
Teresa L AiDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.
Jiani N ChaiDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0003-2560-8218
Vivek DuraiDepartment of Pathology, Division of Immunobiology, Washington University School of Medicine, St. Louis, United States.
Daniel H KaplanDepartment of Dermatology, Department of Immunology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, United States.
Ronald N GermainLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-1495-9143
Kenneth M MurphyDepartment of Pathology, Division of Immunobiology, Washington University School of Medicine, St. Louis, United States.
Chyi-Song HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, United States.
Washington University in St. Louis · USNational Institutes of Health · USUniversity of Pittsburgh · US
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MFunctional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4MUNIQUE ROLES OF ANTIGEN PRESENTING CELLS ON T CELL TOLERANCE AND AUTOIMMUNITYR01AI079187 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S · 2008 to 2021
$5.8MThe Role of Route of Entry by Bacterial Antigens on Colonic T Cell ResponsesR01AI136515 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, NEWBERRY, RODNEY D · 2018 to 2022
$2.8MThe Role of CD101 in T Cell Tolerance in the GutF30DK111071 · NIDDK · WASHINGTON UNIVERSITY · PI RUSSLER-GERMAIN, EMILIE VERONICA · 2016 to 2018
$110kNIAID NIH HHS R01 AI079187NIAID NIH HHS R01 AI136515NIDDK NIH HHS F30 DK111071NIH HHS F30 DK111071NIH HHS T32 GM007200
Abstract
Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103
Indexed as
AnimalsCell DifferentiationCell MovementColonDendritic CellsHelicobacterLymph NodesMiceMice, KnockoutMice, TransgenicT-Lymphocytes, Regulatorycolondendritic cellHelicobacterimmunologyinflammationmicrobiotamouseregulatory t celltolerance
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.