ArticleJournal of the American Chemical Society2021
Total Synthesis of Limaol.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Total Synthesis of Benthol A: The Nominal and the Actual Natural Product.Journal of the American Chemical Society · 2026Article
- Gold catalysis toward the synthesis of natural products: a review.RSC advances · 2026Review
- Total Synthesis of Benthol A: Evidence for a Structure Revision.Journal of the American Chemical Society · 2026Article
- Advancing total synthesis through the Stille cross-coupling: recent innovations and case studies.RSC advances · 2026Review
- Collective Total Synthesis of a Unique Class of Liverworts-Derived Cembrane Diterpenoids.Angewandte Chemie (International ed. in English) · 2025Article
- Total Synthesis of Jerangolid B via spOrganic letters · 2025Article
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Total Synthesis of the Norcembranoid Scabrolide B and Its Transformation into Sinuscalide C, Ineleganolide, and Horiolide.Journal of the American Chemical Society · 2024Article
- Acetal Substitution Reactions: Stereoelectronic Effects, Conformational Analysis, Reactivity vs. Selectivity, and Neighboring-Group Participation.Synlett : accounts and rapid communications in synthetic organic chemistry · 2024Article
- Second-Generation Total Synthesis of Prorocentin.Organic letters · 2023Article
- Total Syntheses of Nominal and Actual Prorocentin.Journal of the American Chemical Society · 2023Article
- Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review.Molecules (Basel, Switzerland) · 2022Review
- Synthesis of Optically ActiveOrganic letters · 2022Article
- P(v) intermediate-mediated E1cB elimination for the synthesis of glycals.Chemical science · 2022Article
- Total Syntheses of Scabrolide A and Nominal Scabrolide B.Journal of the American Chemical Society · 2022Article
- Regioselective trans-Hydrostannation of Boron-Capped Alkynes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A nonthermodynamic array of four skipped methylene substituents on the hydrophobic tail renders limaol, a C40-polyketide of marine origin, unique in structural terms. This conspicuous segment was assembled by a two-directional approach and finally coupled to the polyether domain by an allyl/alkenyl Stille reaction under neutral conditions. The core region itself was prepared via a 3,3'-dibromo-BINOL-catalyzed asymmetric propargylation, a gold-catalyzed spirocyclization, and introduction of the southern sector via substrate-controlled allylation as the key steps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.