Evidence map›Paper›PMID 33533333›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

The impact of continuous positive airway pressure treatment on retinal vascular changes in obstructive sleep apnea.

Brendon Wong, Jessica Y Tong, Angela M Schulz, Stuart L Graham, Claude S Farah, Clare L Fraser

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brendon WongDepartment of Ophthalmology and Vision Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Jessica Y TongDepartment of Ophthalmology and Vision Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Angela M SchulzDepartment of Ophthalmology and Vision Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Stuart L GrahamDepartment of Ophthalmology and Vision Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Claude S FarahMacquarie University Respiratory and Sleep, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Clare L FraserDepartment of Ophthalmology and Vision Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Macquarie University · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) was recently shown to be associated with quantifiable retinal vascular changes, which correlate with disease severity. This follow-up study examines the response of retinal vascular changes in patients with OSA receiving continuous positive airway pressure (CPAP) treatment.

methodsThis prospective cohort study recruited adult patients undergoing diagnostic polysomnography at a tertiary sleep clinic in Sydney, Australia, stratified into 4 groups by the apnea-hypopnea index; control patients and patients with mild, moderate, and severe OSA. At baseline and follow-up approximately 24 months later, static retinal vascular calibers were derived from fundus photographs, and dynamic vascular pulsation amplitudes were measured on video fundoscopy. A proportion of patients started CPAP therapy after baseline assessment.

resultsSeventy-nine patients participated in this follow-up study: 9 control patients and 18 patients with mild OSA, 21 patients with moderate OSA, and 31 patients with severe OSA. Twenty-five patients started CPAP after baseline. In the severe group, patients not on treatment showed progressive narrowing of retinal arteries from baseline, whereas those on CPAP showed a slight improvement (mean, 171.3-165.1 and 171.2-174.0 μm, respectively; P = .012). Arterio-venous ratio was also significantly reduced in the nontreatment group compared to the treatment group in those with severe OSA (0.836-0.821 and 0.837-0.855, respectively; P = .031). CPAP did not seem to have a significant impact on venous caliber or vascular pulsatility.

conclusionsThis study shows that patients with severe untreated OSA demonstrate progressive retinal arterial narrowing, whereas CPAP treatment may be protective.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveAdultAustraliaFollow-Up StudiesHumansProspective Studiescardiovascular diseasecerebrovascular diseasecontinuous positive airway pressure therapyobstructive sleep apnearetinal vasculature

Identifiers

PMID33533333
PMCPMC8320478
OpenAlexW3129134562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.