Evidence map›Paper›PMID 33533327›Full record

Observational studyCardiology in the young2021

Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery.

Katja M Gist, Armin Korst, Stephanie J Nakano, Brian L Stauffer, Anis Karimpour-Fard, Wenru Zhou, Kristen Campbell, Michael F Wempe, Carmen C Sucharov, Shelley D Miyamoto

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cardiology in the young, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katja M GistDepartment of Pediatrics, Division of Pediatric Cardiology, University of Colorado Denver, Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-7427-670X
Armin KorstResearch Institute, Children's Hospital Colorado, Aurora, CO, USA.
Stephanie J NakanoDepartment of Pediatrics, Division of Pediatric Cardiology, University of Colorado Denver, Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, USA.
Brian L StaufferDepartment of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Anis Karimpour-FardDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Wenru ZhouDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kristen CampbellDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael F WempeDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Carmen C SucharovDepartment of Medicine, Division of Cardiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Shelley D MiyamotoDepartment of Pediatrics, Division of Pediatric Cardiology, University of Colorado Denver, Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · USChildren's Hospital Colorado · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Functional Characterization of Phosphodiesterase 1 in Single Ventricle Heart DiseaseK08HL130592 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NAKANO, STEPHANIE JIALING · 2017 to 2021
$826k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS K08 HL130592NHLBI NIH HHS L40 HL133974
6 · The paper itself

Abstract

backgroundMilrinone is a phosphodiesterase type 3 inhibitor that results in a positive inotropic effect in the heart through an increase in cyclic adenosine monophosphate. The purpose of this study was to evaluate circulating cyclic adenosine monophosphate and milrinone concentrations in milrinone treated paediatric patients undergoing congenital heart surgery.

methodsSingle-centre prospective observational pilot study from January 2015 to December 2017 including children aged birth to 18 years. Milrinone and circulating cyclic adenosine monophosphate concentrations were measured at four time points through the first post-operative day and compared between patients with and without low cardiac output syndrome, defined using clinical and laboratory criteria.

resultsFifty patients were included. Nine (18%) developed low cardiac output syndrome. For all patients, 22% had single ventricle heart disease. The density and distribution of cyclic adenosine monophosphate concentrations varied between those with and without low cardiac output syndrome but were not significantly different. Milrinone concentrations increased in all patients. Paired t-tests demonstrated an increase in circulating cyclic adenosine monophosphate concentrations during the post-operative period among patients without low cardiac output syndrome.

conclusionsIn this prospective observational study, circulating cyclic adenosine monophosphate concentrations increased in those without low cardiac output syndrome during the first 24 post-operative hours and milrinone concentrations increased in all patients. Further study of the utility of cyclic adenosine monophosphate concentrations in milrinone treated patients is necessary.

Indexed as

Heart Defects, CongenitalMilrinoneAdenosine MonophosphateCardiac Output, LowCardiotonic AgentsChildHumansProspective StudiesAdenosine MonophosphateCardiotonic AgentsMilrinonecAMPcongenital heart surgerylow cardiac output syndromeMilrinonepediatrics

Identifiers

PMID33533327
PMCPMC9257900
OpenAlexW3127973737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.