Evidence map›Paper›PMID 33533313›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Lack of evidence for impaired preload or Bezold-Jarisch activation during brief umbilical cord occlusions in fetal sheep.

Christopher A Lear, Laura Bennet, Benjamin A Lear, Jenny A Westgate, Alistair J Gunn

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Reply to Smolich and Mynard.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  3. Reply to "Bezold-Jarisch reflex in the near-term fetus during labor: a matter of time".American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher A LearFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8937-0846
Laura BennetFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Benjamin A LearFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0970-3063
Jenny A WestgateFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Alistair J GunnFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0656-7035
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired cardiac preload secondary to umbilical cord occlusion (UCO) has been hypothesized to contribute to intrapartum decelerations, brief falls in fetal heart rate (FHR), through activation of the Bezold-Jarisch reflex. This cardioprotective reflex increases parasympathetic and inhibits sympathetic outflows triggering hypotension, bradycardia, and peripheral vasodilation, but its potential to contribute to intrapartum decelerations has never been systematically examined. In this study, we performed bilateral cervical vagotomy to remove the afferent arm and the efferent parasympathetic arm of the Bezold-Jarisch reflex. Twenty-two chronically instrumented fetal sheep at 0.85 of gestation received vagotomy (

Indexed as

HemodynamicsReflexVentricular FunctionAnimalsAutonomic Nervous SystemBlood Flow VelocityBlood PressureCarotid ArteriesConstrictionFemoral ArteryFetal HeartHeart Rate, FetalSheep, DomesticTime FactorsUmbilical CordUterine ContractionBezold-Jarischfetal heart ratehypoxemiaintrapartum decelerationsvagotomy

Identifiers

PMID33533313
OpenAlexW3128304992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.