Evidence map›Paper›PMID 33533300›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma.

Ryan C Murphy, Ying Lai, James D Nolin, Robier A Aguillon Prada, Arindam Chakrabarti, Michael V Novotny, Michael C Seeds, William A Altemeier, Michael H Gelb, Robert Duncan Hite and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ryan C MurphyDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0003-0094-0003
Ying LaiDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.
James D NolinDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.
Robier A Aguillon PradaDepartment of Critical Care, Cleveland Clinic, Cleveland, Ohio.
Arindam ChakrabartiDepartment of Critical Care, Cleveland Clinic, Cleveland, Ohio.
Michael V NovotnyDepartment of Critical Care, Cleveland Clinic, Cleveland, Ohio.
Michael C SeedsSection on Molecular Medicine, Wake Forest University, Winston-Salem, North Carolina.
William A AltemeierDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0001-8860-405X
Michael H GelbDepartment of Chemistry, University of Washington, Seattle, Washington.
Robert Duncan HiteDivision of Pulmonary Disease & Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, Ohio.
Teal S HallstrandDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.
University of Washington · USCleveland Clinic · USUniversity of Cincinnati · USWake Forest University · US

Funding

Secretory Phospholipase A2s in Airway PathophysiologyR01HL089215 · NHLBI · UNIVERSITY OF WASHINGTON · PI HALLSTRAND, TEAL S · 2008 to 2017
$4.0M
Immunopathology of Indirect Airway Hyperresponsiveness in AsthmaK24AI130263 · NIAID · UNIVERSITY OF WASHINGTON · PI Teal S Hallstrand · 2017 to 2026
$1.3M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL089215HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) K24AI130263NHLBI NIH HHS R01 HL089215NIAID NIH HHS K24 AI130263
6 · The paper itself

Abstract

The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and lipid mediator release in relation to AHR severity and changes induced by exercise challenge. Paired induced sputum (

Indexed as

ExerciseAdolescentAdultAsthmaBronchoconstrictionEicosanoidsFemaleGroup X Phospholipases A2HumansHydrolysisMaleOsmotic PressurePhospholipidsRespiratory HypersensitivitySputumSurface-Active AgentsEicosanoidsGroup X Phospholipases A2PhospholipidsPLA2G10 protein, humanSurface-Active Agentsairway hyperresponsivenessasthmaeicosanoidphospholipase A2surfactant

Identifiers

PMID33533300
PMCPMC8174822
OpenAlexW3126434654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.