ArticleMagnetic resonance in medicine2021
PreQual: An automated pipeline for integrated preprocessing and quality assurance of diffusion weighted MRI images.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
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- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.Stroke · 2026Article
- Article
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- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Along-Tract Microstructural Alterations Associated with Stimulant Misuse Localized using Diffusion MRI Tractometry.bioRxiv : the preprint server for biology · 2026Article
- Did you know? State-of-the-art preprocessing diffusion MRI data can improve tractography.Brain structure & function · 2026Review
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.bioRxiv : the preprint server for biology · 2026Article
- Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Longitudinal quantitative streamline tractography: robust estimation of white matter connectivity differences.bioRxiv : the preprint server for biology · 2026Article
- Iterative learning for joint image denoising and motion artifact correction of 3D brain MRI.Medical image analysis · 2026Article
- Characterizing Continuous and Discrete Hybrid Latent Spaces for Structural Connectomes.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Personalized White Matter Bundle Segmentation for Early Childhood.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- The average does not represent the individual: White matter variability across the brain, across the population, and across the lifespan.Research square · 2026Article
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Is correction for gradient nonlinearity necessary in a brain diffusion tensor MRI clinical study?PloS one · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
purposeDiffusion weighted MRI imaging (DWI) is often subject to low signal-to-noise ratios (SNRs) and artifacts. Recent work has produced software tools that can correct individual problems, but these tools have not been combined with each other and with quality assurance (QA). A single integrated pipeline is proposed to perform DWI preprocessing with a spectrum of tools and produce an intuitive QA document.
methodsThe proposed pipeline, built around the FSL, MRTrix3, and ANTs software packages, performs DWI denoising; inter-scan intensity normalization; susceptibility-, eddy current-, and motion-induced artifact correction; and slice-wise signal drop-out imputation. To perform QA on the raw and preprocessed data and each preprocessing operation, the pipeline documents qualitative visualizations, quantitative plots, gradient verifications, and tensor goodness-of-fit and fractional anisotropy analyses.
resultsRaw DWI data were preprocessed and quality checked with the proposed pipeline and demonstrated improved SNRs; physiologic intensity ratios; corrected susceptibility-, eddy current-, and motion-induced artifacts; imputed signal-lost slices; and improved tensor fits. The pipeline identified incorrect gradient configurations and file-type conversion errors and was shown to be effective on externally available datasets.
conclusionsThe proposed pipeline is a single integrated pipeline that combines established diffusion preprocessing tools from major MRI-focused software packages with intuitive QA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.