Evidence map›Paper›PMID 33533057›Full record

ArticleClinical anatomy (New York, N.Y.)2021

Characterizing the coalescence area of conjoined twins to elucidate congenital disorders in singletons.

Lucas L Boer, Annelieke N Schepens-Franke, Eduard Winter, Roelof-Jan Oostra

Abstract read
In one paragraph

Article in Clinical anatomy (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Dutch teratological collections and their artistic portrayals.American journal of medical genetics. Part C, Seminars in medical genetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lucas L BoerDepartment of Imaging, Section Anatomy and Museum for Anatomy and Pathology, Radboud University, Medical Center, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0003-1564-0847
Annelieke N Schepens-FrankeDepartment of Imaging, Section Anatomy and Museum for Anatomy and Pathology, Radboud University, Medical Center, Nijmegen, Netherlands.
Eduard WinterPathologisch-anatomische Sammlung im Narrenturm-NHM, Vienna, Austria.
Roelof-Jan OostraDepartment of Medical Biology, Sections Clinical Anatomy & Embryology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Netherlands.ORCID https://orcid.org/0000-0002-2452-8307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shared anomalies, always located close to the area of coalescence and observable in virtually every type of conjoined twinning, are currently seen as separate anomalies caused by mostly unknown and seemingly unrelated pathways rather than being connected to the twinning mechanism itself. Therefore, most (case) reports about conjoined twins are mere descriptions of (external) dysmorphologies lacking reflections on the possible origin of their concomitant anomalies. As we will demonstrate in this article, shared anomalies are influenced, and in some cases solely and sequentially explained, by interaction aplasia and neo-axial orientation; two embryological mechanisms to which each set of conjoined twins is subjected and are responsible for their ultimate phenotypical fate. In this review, we consider how the ventral, lateral and caudal conjunction types and their intermediates determine the phenotypic presentation of the twins, including patterns of shared malformations and anomalies, which in themselves can be indistinguishable from those encountered in singleton cases. Hence, it can be hypothesized that certain anomalies in singletons originate in a fashion similar to that in conjoined twins.

Indexed as

Abnormalities, MultipleTwins, ConjoinedCadaverHumansconcomitant anomaliesconjoined twinsholoprosencephalyneural tube defectsOEISsirenomelia

Identifiers

PMID33533057
PMCPMC8451816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.