Evidence map›Paper›PMID 33533036›Full record

SynthesisInternational journal of dermatology2021

Skin manifestations in COVID-19 patients, state of the art. A systematic review.

Andrea Perna, Marco Passiatore, Antonio Massaro, Alessandro Terrinoni, Luca Bianchi, Vitale Cilli, Marco D'Orio, Luca Proietti, Giuseppe Taccardo, Rocco De Vitis

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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  18. Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Andrea PernaIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Marco PassiatoreIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Antonio MassaroUnità Operativa di Dermatologia, Dipartimento di Medicina dei Sistemi, Università di Roma Tor Vergata, Roma, Italia.
Alessandro TerrinoniDipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Roma, Italia.
Luca BianchiUnità Operativa di Dermatologia, Dipartimento di Medicina dei Sistemi, Università di Roma Tor Vergata, Roma, Italia.
Vitale CilliChirurgie de la Main, CHIREC site Delta, Bruxelles, Belgique.
Marco D'OrioIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Luca ProiettiIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Giuseppe TaccardoIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Rocco De VitisIstituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Agostino Gemelli University Polyclinic · ITUniversity of Rome Tor Vergata · ITCentre Hospitalier Interrégional Edith Cavell · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince COVID-19 has become a pandemic, extensive literature has been produced. The commonest symptoms of COVID-19 disease are fever, cough, anosmia, and lymphocytopenia. However, other apparently less common clinical symptoms have been described, including skin lesions. We conducted a systematic review to evaluate skin involvement in COVID-19.

methodsThe authors performed a systematic review of literature, in accordance with the Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA). The search was reiterated until May 06, 2020.

resultsOverall, 1593 patients (M/F ratio: 1 : 9) with suspect of COVID-19 were examined. The mean age was 37.8 (range 0-91) years. Among the analyzed patients, 84 (5.3%) were pediatrics (<18 years). Chilblains are very common among skin lesions and represent almost half of all skin lesions reported (46%); in 75% of patients with cutaneous manifestation, the latter presented before other typical clinical manifestation of COVID-19. Vasculitis or thrombosis was identified in almost 70% of patients who suffered from skin manifestations.

conclusionThe present study highlights the importance of skin involvement in COVID-19. Limbs should be examined to eventually foresee the onset of further typical symptoms. Chilblains can be considered typical features. Studies with higher scientific evidence are required.

Indexed as

ChilblainsCOVID-19HumansPandemicsSkin DiseasesThrombosisVasculitis

Identifiers

PMID33533036
PMCPMC8014166
OpenAlexW3126417247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.