Evidence map›Paper›PMID 33533011›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021

Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation.

Aline Bamia, Maha Sinane, Rima Naït-Saïdi, Jamila Dhiab, Marc Keruzoré, Phu Hai Nguyen, Agathe Bertho, Flavie Soubigou, Sophie Halliez, Marc Blondel and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Insights into the Diagnosis, Treatment, and Management of Prion Diseases.CNS & neurological disorders drug targets · 2026
    Review
  2. Review
  3. Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Aline Bamia *Inserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Maha Sinane *Inserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Rima Naït-Saïdi *Institute of Human Genetics, UMR9002 CNRS-Univ Montpellier, mRNA Regulation and Development, Montpellier, France.
Jamila Dhiab *Sorbanne Université, Inserm, Institut de Myologie, Centre de Recherche en Myologie, F75013, Paris, France.
Marc KeruzoréInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Phu Hai NguyenInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Agathe BerthoInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Flavie SoubigouInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Sophie HalliezINRAE, UVSQ, VIM, Université Paris-Saclay, Jouy-en-Josas, France.
Marc BlondelInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Capucine TrolletSorbanne Université, Inserm, Institut de Myologie, Centre de Recherche en Myologie, F75013, Paris, France.
Martine SimoneligInstitute of Human Genetics, UMR9002 CNRS-Univ Montpellier, mRNA Regulation and Development, Montpellier, France.
Gaëlle FriocourtInserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France.
Vincent BéringueINRAE, UVSQ, VIM, Université Paris-Saclay, Jouy-en-Josas, France.
Frédéric Bihel *Laboratoire d'Innovation Thérapeutique, LIT, UMR7200, IMS MEDALIS, Faculty of Pharmacy, CNRS, Université de Strasbourg, Illkirch, F-67400, France. frederic.bihel@unistra.fr.
Cécile Voisset *Inserm, Univ Brest, EFS, UMR 1078, GGB, F-29200, Brest, France. cecile.voisset@univ-brest.fr.ORCID http://orcid.org/0000-0001-7505-1927
Inserm · FRCentre National de la Recherche Scientifique · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prion diseases are caused by the propagation of PrP

Indexed as

AnimalsCalcium Channel BlockersCell LineDatabases, FactualDrosophilaDrug Delivery SystemsFemaleFlunarizineMiceMice, TransgenicOrgan Culture TechniquesPoly(A)-Binding Protein IPrion DiseasesPrion ProteinsProtein AggregatesProtein FoldingCalcium Channel BlockersFlunarizinePABPN1 protein, mousePoly(A)-Binding Protein IPrion ProteinsProtein Aggregatesdrug repositioningOPMDPABPN1PFARPrionsPrPSc

Identifiers

PMID33533011
PMCPMC8423950
OpenAlexW3128374093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.