Evidence map›Paper›PMID 33532995›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2021

The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial.

Jin Sun Cho, Na Young Kim, Jae-Kwang Shim, Ji Hae Jun, Sugeun Lee, Young-Lan Kwak

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03273231 (The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03273231 naunknown statusnot on this map

The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

TypeinterventionalSponsorYonsei UniversityRan2017 to 2020Enrolled100ConditionsColorectal CancerArmsKetamine, Saline
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  17. Anesthesia and cancer.Revista da Associacao Medica Brasileira (1992) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jin Sun ChoDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Na Young KimDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Jae-Kwang ShimDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Ji Hae JunAnesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sugeun LeeDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Young-Lan KwakDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. ylkwak@yuhs.ac.ORCID http://orcid.org/0000-0002-2984-9927
Yonsei University · KR

Funding

National Research Foundation of Korea 2017R1C1B5018102
6 · The paper itself

Abstract

purposeKetamine's inhibitory action on the N-methyl-D-aspartate receptor and anti-inflammatory effects may provide beneficial immunomodulation in cancer surgery. We investigated the effect of subanesthetic-dose ketamine as an adjunct to desflurane anesthesia on natural killer (NK) cell activity and inflammation in patients undergoing colorectal cancer surgery.

methodsA total of 100 patients were randomly assigned to a control or ketamine group. The ketamine group received a bolus of 0.25 mg·kg

resultsThe NK cell activity was significantly decreased after surgery in both groups, but the change was not different between groups in the linear mixed model analysis (P = 0.47). Changes in IL-6, TNF-α, CRP, and carcinoembryonic antigen levels were not different between groups (P = 0.27, 0.69, 0.99, and 0.97, respectively). Cancer recurrence within 2 years after surgery was similar between groups (10% vs 8%, P = 0.62).

conclusionsIntraoperative low-dose ketamine administration did not convey any favourable impacts on overall postoperative NK cell activity, inflammatory responses, and prognosis in colorectal cancer surgery patients.

trial registrationwww.clinicaltrial.gov (NCT03273231); registered 6 September 2017.

Indexed as

Colorectal NeoplasmsKetamineDouble-Blind MethodHumansImmunomodulationInterleukin-6Tumor Necrosis Factor-alphaInterleukin-6KetamineTumor Necrosis Factor-alphacancer surgerycolorectal cancerimmunityinflammationketaminenatural killer cell

Identifiers

PMID33532995
OpenAlexW3128131100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.