ArticleCerebellum (London, England)2021
Relationship Between Early Functional and Structural Brain Developments and Brain Injury in Preterm Infants.
Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Sensory-based interventions in the NICU: systematic review of effects on preterm brain development.Pediatric research · 2022Pooled it
- Cerebellar Development and the Burden of Prematurity.Cerebellum (London, England) · 2025Review
- Construction of an early diagnostic model for brain injury in premature infants based on combined amplitude-integrated electroencephalography and cranial ultrasound parameters.American journal of translational research · 2025Article
- Sleep as a driver of pre- and postnatal brain development.Pediatric research · 2024Review
- Machine Learning-Derived Active Sleep as an Early Predictor of White Matter Development in Preterm Infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Early EEG-burst sharpness and 2-year disability in extremely preterm infants.Pediatric research · 2024Article
- Commentary - Cerebellar underdevelopment in the very preterm infant: Important and underestimated source of cognitive deficits.Journal of neonatal-perinatal medicine · 2021Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundRecent studies explored the relationship between early brain function and brain morphology, based on the hypothesis that increased brain activity can positively affect structural brain development and that excitatory neuronal activity stimulates myelination.
objectiveTo investigate the relationship between maturational features from early and serial aEEGs after premature birth and MRI metrics characterizing structural brain development and injury, measured around 30weeks postmenstrual age (PMA) and at term. Moreover, we aimed to verify whether previously developed maturational EEG features are related with PMA. DESIGN/
methodsOne hundred six extremely preterm infants received bedside aEEGs during the first 72h and weekly until week 5. 3T-MRIs were performed at 30weeks PMA and at term. Specific features were extracted to assess EEG maturation: (1) the spectral content, (2) the continuity [percentage of spontaneous activity transients (SAT%) and the interburst interval (IBI)], and (3) the complexity. Automatic MRI segmentation to assess volumes and MRI score was performed. The relationship between the maturational EEG features and MRI measures was investigated.
resultsBoth SAT% and EEG complexity were correlated with PMA. IBI was inversely associated with PMA. Complexity features had a positive correlation with the cerebellar size at 30weeks, while event-based measures were related to the cerebellar size at term. Cerebellar width, cortical grey matter, and total brain volume at term were inversely correlated with the relative power in the higher frequency bands.
conclusionsThe continuity and complexity of the EEG steadily increase with increasing postnatal age. Increasing complexity and event-based features are associated with cerebellar size, a structure with enormous development during preterm life. Brain activity is important for later structural brain development.
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