Evidence map›Paper›PMID 33532793›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: the UK Biobank cohort study.

Camille Lassale, Mark Hamer, Álvaro Hernáez, Catharine R Gale, G David Batty

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Camille LassaleHospital del Mar Medical Research Institute, Barcelona, Spain.
Mark HamerDivision of Surgery and Interventional Sciences, University College London, London, UK.
Álvaro HernáezHospital del Mar Medical Research Institute, Barcelona, Spain.
Catharine R GaleMRC Lifecourse Epidemiology Unit, University of Southampton, UK.
G David BattyDepartment of Epidemiology and Public Health, University College London, London.
Instituto de Salud Carlos III · ESUniversity College London · GBNHS Lothian · GB

Funding

Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60R01AG052519 · NIA · UNIVERSITY COLLEGE LONDON · PI BATTY, DAVID, GOODMAN, ALISSA · 2017 to 2021
$1.9M
Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60R56AG052519 · NIA · UNIVERSITY COLLEGE LONDON · PI BATTY, DAVID, GOODMAN, ALISSA · 2016 to 2016
$500k
NIA NIH HHS R01 AG052519NIA NIH HHS R56 AG052519
6 · The paper itself

Abstract

objectiveThere is growing evidence of, and biological plausibility for, elevated levels of high-density lipoprotein cholesterol (HDL-C), being related to lower rates of severe infection. Accordingly, we tested whether pre-pandemic HDL-C within the normal range is associated with subsequent COVID-19 hospitalisations and death. APPROACH: We analysed data on 317,306 participants from UK Biobank, a prospective cohort study, baseline data for which were collected between 2006 and 2010. Follow-up for COVID-19 was via hospitalisation records and a national mortality registry.

resultsAfter controlling for a series of confounding factors which included health behaviours, inflammatory markers, and socio-economic status, higher levels of HDL-C were related to a lower risk of later hospitalisation for COVID-19. The effect was linear (p-value for trend 0.001) such that a 0.2 mmol/L increase in HDL-C was associated with a corresponding 9% reduction in risk (odds ratio; 95% confidence interval: 0.91; 0.86, 0.96). A very similar pattern of association was apparent when COVID-19 mortality was the outcome of interest (odds ratio per 0.2 mmol/l increase in HDL-C: 0.90; 0.81, 1.00); again, a stepwise effect was evident (p-value for trend 0.03).

conclusionsThese novel results for HDL-C and COVID-19 events warrant testing in other studies.

Identifiers

PMID33532793
PMCPMC7852244
OpenAlexW3125040510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.