Evidence map›Paper›PMID 33532782›Full record

ArticlebioRxiv : the preprint server for biology2021

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques.

Xuan He, Abishek Chandrashekar, Roland Zahn, Frank Wegmann, Jingyou Yu, Noe B Mercado, Katherine McMahan, Amanda J Martinot, Cesar Piedra-Mora, Sidney Beecy and 22 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 4 institutions in 2 countries.

Abishek ChandrashekarORCID 0000-0001-7821-5552
Roland Zahn
Jingyou Yu
Katherine McMahan
Amanda J MartinotORCID 0000-0001-6237-6191
Cesar Piedra-MoraORCID 0000-0003-1146-7717
Sidney Beecy
Sietske Rosendahl HuberORCID 0000-0002-6214-374X
Leslie van der Fits
Erica N Borducchi
Michelle Lifton
Jinyan Liu
Felix Nampanya
Shivani Patel
Lisa H TostanoskiORCID 0000-0001-9255-5684
Laurent Pessaint
Alex Van Ry
Brad Finneyfrock
Jason Velasco
Elyse Teow
Renita Brown
Anthony Cook
Hanne Andersen
Hanneke SchuitemakerORCID 0000-0001-8563-2266
Beth Israel Deaconess Medical Center · USBioqual · USJanssen (Netherlands) · NLTufts University · US

Funding

Optimization of Broadly Neutralizing Antibodies for HIV EradicationR01AI129797 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2017 to 2021
$3.6M
High-Throughput TB Vaccine Antigen DiscoveryK08AI135098 · NIAID · TUFTS UNIVERSITY BOSTON · PI MARTINOT, AMANDA · 2018 to 2022
$931k
NIAID NIH HHS K08 AI135098
6 · The paper itself

Abstract

We previously reported that a single immunization with an adenovirus serotype 26 (Ad26) vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. In this study, we evaluated the immunogenicity and protective efficacy of reduced doses of Ad26.COV2.S. 30 rhesus macaques were immunized once with 1×10

Identifiers

PMID33532782
PMCPMC7852276
OpenAlexW3122454871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.