ArticleClinical and translational radiation oncology2021
The individual risk of symptomatic radionecrosis after brain metastasis radiosurgery is predicted by a continuous function of the V12Gy.
Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of stereotactic radiosurgery dose on local control and radiation necrosis in metastatic brain lesions: a comparative study.Frontiers in oncology · 2026Article
- Dual optimization in single-isocenter radiosurgery for multiple brain metastases: a dosimetric planning study.Frontiers in oncology · 2026Article
- Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.Zeitschrift fur medizinische Physik · 2025Article
- Stereotactic radiosurgery for multiple small brain metastases using gamma knife versus single-isocenter VMAT: Normal brain dose based on lesion number and size.Journal of applied clinical medical physics · 2025Article
- Stereotactic radiotherapy for metastatic brain tumors: A comparative analysis of dose distributions among VMAT, Helical TomoTherapy, CyberKnife, Gamma Knife, and ZAP-X.Journal of applied clinical medical physics · 2025Article
- HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy.Advances in radiation oncology · 2025Article
- Effect of prescription isodose line on tissue sparing in linear accelerator-based stereotactic radiosurgery treating multiple brain metastases using dynamic conformal arcs.Journal of applied clinical medical physics · 2024Article
- Characterization of cerebral radiation necrosis following the treatment of sinonasal malignancies.Laryngoscope investigative otolaryngology · 2024Article
- Article
- Outcomes Following Early Postoperative Adjuvant Radiosurgery for Brain Metastases.JAMA network open · 2023Article
- Impressive reduction of brain metastasis radionecrosis after cabozantinib therapy in metastatic renal carcinoma: A case report and review of the literature.Frontiers in oncology · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionBrain metastases are frequently treated with stereotactic radiosurgery (SRS). Radionecrosis (RN) is the late side effect in up to 24% of patients, being symptomatic in 8-10%. Fixed values of the radiosurgical volume receiving 12 Gy or more (V12Gy) are used to roughly predict the global risk. The aim of this retrospective study is to fine-tune the model of individual risk prediction for symptomatic radionecrosis and identify modulating factors. MATERIALS AND
methodsData of patients treated with SRS for ≤3 BM of solid tumours at CHU-UCL-Namur were retrospectively reviewed. Doses ranging from 15 to 24 Gy were prescribed to the 70% isodose in function of the lesion diameter. Treatment was administered with a stereotactic linear accelerator. Follow-up magnetic resonance imaging was performed 3-monthly for 18 months and 6-monthly thereafter. RN was prospectively diagnosed and confirmed by the tumour board. V12Gy, previous or salvage whole-brain radiotherapy (WBRT), smoking history, diabetes, postoperative SRS, diagnosis-specific graded prognostic assessment score, cerebral lobe location and relative location (superficial versus deep) were retrieved. Univariate and multivariate analyses were performed to assess their predictive values and derive a model.
results128 patients with 220 lesions were analysed. The risk of RN was predicted by a continuous function of the V12Gy (p = 0.005). No other factor had a significant impact, particularly WBRT that did not increase the risk.
conclusionThe risk of symptomatic RN is predicted on an individual basis by a model in function of the V12Gy and must be confirmed in a prospective study.
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