ArticleClinical and translational radiation oncology2021
Evaluation of daily online contour adaptation by radiation therapists for prostate cancer treatment on an MRI-guided linear accelerator.
Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07043543 (Randomized Open Phase II Multienter Study Evaluating the Clinical Utility of Online Adaptive Radiotherapy in Bladder Cancer), which is not on this map. Cited by 43 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Open Phase II Multienter Study Evaluating the Clinical Utility of Online Adaptive Radiotherapy in Bladder Cancer
Who cites it
43 citing papers in PubMed, 56 citations in OpenAlex.
- Online adaptive radiotherapy: International strategies for AI-enabled workflow efficiency and radiation therapist-led delivery for sustainable practice.Technical innovations & patient support in radiation oncology · 2026Article
- Automated workflow for target volume propagation in online adaptive magnetic resonance guided radiotherapy for lung lesions using foundation models.Physics and imaging in radiation oncology · 2026Article
- Transition from Oncologist- to Therapist-Led MRI-Guided Ultra-Hypofractionated Adaptive Prostate Radiation Therapy: Evaluation of Early Clinical Outcomes.Current oncology (Toronto, Ont.) · 2026Article
- Practice development perspective of RTT contouring in online adaptive radiotherapy for prostate cancer: A single-centre cost-consequence analysis.Technical innovations & patient support in radiation oncology · 2026Article
- Optimal timing of the cumulative dose and factors related to acute urinary toxicity in prostate cancer treated using magnetic resonance linear accelerator.Radiological physics and technology · 2026Article
- Terminology Proposal for Adaptive Particle Therapy Classification and Strategies.International journal of particle therapy · 2026Article
- Impact of health system interventions to improve access to external beam radiotherapy: a scoping review.Frontiers in oncology · 2026Review
- Feasibility of reusing online-generated treatment plans for adaptive radiotherapy in prostate cancer.Physics and imaging in radiation oncology · 2026Article
- Feasibility of Therapist-Driven MR-Guided Adaptive Radiotherapy for Oligometastatic Disease: Geometric Accuracy and Dosimetric Impact.Journal of medical imaging and radiation oncology · 2025Article
- Towards clinical implementation of T2-weighted cine imaging for intrafraction drift correction workflows on the 1.5 Tesla magnetic resonance-linear accelerator.Physics and imaging in radiation oncology · 2025Article
- Apparent diffusion coefficient as a quantitative biomarker for prostate cancer treatment response on a 1.5 Tesla magnetic resonance-linear accelerator: Impact of image registration and acquisition type.Physics and imaging in radiation oncology · 2025Article
- The Value of Radiation Therapists in Online Adaptive Radiotherapy.Journal of medical radiation sciences · 2025Article
- Evaluation of therapeutic radiographer target volume contouring for magnetic resonance image guided online adaptive bladder radiotherapy.Clinical and translational radiation oncology · 2025Article
- Diagnostic image-based treatment planning for online adaptive ultra-hypofractionated prostate cancer radiotherapy with MR-Linac.Journal of applied clinical medical physics · 2025Article
- Geometric and dosimetric evaluation of CTV contour adaptations by radiation therapists for adaptive prostate radiotherapy on a 0.35 T MR-Linac.Technical innovations & patient support in radiation oncology · 2025Article
- Pan-Canadian assessment of image guided adaptive radiation therapy and the role of the radiation therapist.Technical innovations & patient support in radiation oncology · 2025Article
- Training for tomorrow: Establishing a worldwide curriculum in online adaptive radiation therapy.Technical innovations & patient support in radiation oncology · 2025Article
- Treatment time and learning curve analysis of 1.5 T MR-Linac workflows led by radiation oncologists or therapists.Clinical and translational radiation oncology · 2025Article
- First-in-Men Online Adaptive Robotic Stereotactic Body Radiation Therapy: Toward Ultrahypofractionation for High-Risk Prostate Cancer Patients.Advances in radiation oncology · 2025Article
- Clinical implementation of RTT-only CBCT-guided online adaptive focal radiotherapy for bladder cancer.Clinical and translational radiation oncology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMagnetic resonance (MR)-guided linear accelerator (MR-Linac) systems have changed radiotherapy workflows. The addition of daily online contour adaptation allows for higher precision treatment, but also increases the workload of those involved. We train radiation therapists (RTTs) to perform daily online contour adaptation for MR-Linac treatment of prostate cancer (PCa) patients. The purpose of this study was to evaluate these prostate contours by performing an interfraction and interobserver analysis. MATERIALS AND
methodsClinical target volume (CTV) contours generated online by RTTs from 30 low-intermediate risk PCa patients, treated with 5x7.25 Gy, were used. Two physicians (Observers) judged the RTTs contours and performed adaptations when necessary. Interfraction relative volume differences between the first and the subsequent fractions were calculated for the RTTs, Observer 1, and Observer 2. Additionally, interobserver dice's similarity coefficient (DSC) for fraction 2-5 was calculated with the RTTs- and physician-adapted contours. Clinical acceptability of the RTTs contours was judged by a third observer.
resultsMean (SD) online contour adaptation time was 12.6 (±3.8) minutes and overall median (interquartile range [IQR]) relative volume difference was 9.3% (4.4-13.0). Adaptations by the observers were mostly performed at the apex and base of the prostate. Median (IQR) interobserver DSC between RTTs and Observer 1, RTTs and Observer 2, and Observer 1 and 2 was 0.99 (0.98-1.00), 1.00 (0.98-1.00), and 1.00 (0.99-1.00), respectively. Contours were acceptable for clinical use in 113 (94.2%) fractions. Dose-volume histogram (DVH) analysis showed significant CTV underdosage for one of the seven identified outliers.
conclusionDaily online contour adaptation by RTTs is clinically feasible for MR-Linac treatment of PCa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.