ArticleSSM - population health2021
Accelerated aging: A marker for social factors resulting in cardiovascular events?
Article in SSM - population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Accelerated metabolomic aging and its association with social determinants of health in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Social determinants of health and biological age among diverse U.S. Adults, NHANES 2011-2018.BMC public health · 2025Article
- Examining the Health Risk Pathways Between Discrimination and Accelerated Biological Aging Among a Population-Based Sample of Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time.Environmental health perspectives · 2025Article
- Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy.Circulation. Cardiovascular quality and outcomes · 2025Article
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy.Cancer medicine · 2025Article
- Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study.GeroScience · 2024Article
- Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- The Role of Aging in Intracerebral Hemorrhage.Brain sciences · 2024Review
- A Comparison of 5 Measures of Accelerated Biological Aging and Their Association With Incident Cardiovascular Disease: The CARDIA Study.Journal of the American Heart Association · 2024Article
- Discrimination and bladder health among women in the CARDIA cohort study: Life course and intersectionality perspectives.Social science & medicine (1982) · 2024Article
- Review
- Accelerated Aging and the Life Course of Individuals Born Preterm.Children (Basel, Switzerland) · 2023Review
- Weathering within war: Somatic health complaints among Vietnamese older adults exposed to bombing and violence as adolescents in the American war.Journal of psychosomatic research · 2023Article
- Navigating Black Aging: The Biological Consequences of Stress and Depression.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- A cross-sectional analysis of racial differences in accelerated aging and cognitive function among patients with atrial fibrillation: The SAGE-AF study: Forrester, Accelerated aging and cognitive function.EClinicalMedicine · 2021Article
- The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8.Journal of the American College of Cardiology · 2021Review
- Racial and Ethnic Disparities in Blood Pressure and Glycemic Control in the US Community Health Center Patient Population.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMedicine and public health are shifting away from a purely "personal responsibility" model of cardiovascular disease (CVD) prevention towards a societal view targeting social and environmental conditions and how these result in disease. Given the strong association between social conditions and CVD outcomes, we hypothesize that accelerated aging, measuring earlier health decline associated with chronological aging through a combination of biomarkers, may be a marker for the association between social conditions and CVD.
methodsWe used data from the Coronary Artery Risk Development in Young Adults study (CARDIA). Accelerated aging was defined as the difference between biological and chronological age. Biological age was derived as a combination of 7 biomarkers (total cholesterol, HDL, glucose, BMI, CRP, FEV1/h
resultsAmong 2978 middle-aged participants, mean (SD) accelerated aging was 3.6 (11.6) years, i.e., the CARDIA cohort appeared to be, on average, 3 years older than its chronological age. Accelerated aging partially mediated the association between social factors and CVD (N=219), stroke (N=36), and mortality (N=59). Accelerated aging mediated 41% of the total effects of racial discrimination on stroke after adjustment for covariates. Accelerated aging also mediated other relationships but to lesser degrees.
conclusionWe provide new evidence that accelerated aging based on easily measurable biomarkers may be a viable marker to partially explain how social factors can lead to cardiovascular outcomes and death.
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