ArticleERJ open research2021
Aspiration and severe exacerbations in COPD: a prospective study.
Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Risk of pneumonia in adults with chronic cough: a nationwide cohort study.BMJ open respiratory research · 2026Article
- The association between dysphagia and the risk of acute exacerbation of COPD: a systematic review and meta-analysis.ERJ open research · 2026Article
- Cost effectiveness of a novel swallowing and respiratory sensation assessment and a modelled intervention to reduce acute exacerbations of COPD.BMC pulmonary medicine · 2025Article
- Study on predictive models for swallowing risk in patients with AECOPD.BMC pulmonary medicine · 2024Article
- Chronic cough associated with COPD exacerbation, pneumonia and death in the general population.ERJ open research · 2024Article
- Videofluoroscopic measures of swallowing in people with stable COPD compared to healthy aging.CoDAS · 2023Article
- Swallow patterns associated with aspiration in COPD: a prospective analysis.ERJ open research · 2021Article
- Tongue strength and swallowing dynamics in chronic obstructive pulmonary disease.ERJ open research · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSwallow may be compromised in COPD leading to aspiration and adverse respiratory consequences. However, prevalence and consequences of detectable aspiration in stable COPD are not known.
objectivesWe tested the hypothesis that a significant number of patients with stable COPD will have detectable aspiration during swallow (prandial aspiration) and that they would experience more frequent severe acute exacerbations of COPD (AECOPD) over the subsequent 12 months.
methodsPatients (n=151) with verified and stable COPD of all severities were recruited at a tertiary care hospital. Videofluoroscopy was conducted to evaluate aspiration using Rosenbek's scale for penetration-aspiration during 100-mL cup drinking. AECOPD was documented as moderate (antibiotics and/or corticosteroid treatment) or severe (emergency department admission or hospitalisation) over the ensuing 12 months. MEASUREMENTS AND MAIN
resultsAspiration was observed in 30 out of 151 patients (19.9%, 18 males, 12 females; mean age 72.4 years). Patients with aspiration had more overall AECOPD events (3.03
conclusionsPrandial aspiration is detectable in a subset of patients with COPD and was predictive of subsequent severe AECOPD. Studies to examine if the association is causal are essential to direct strategies aimed at prevention of aspiration and AECOPD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.