ArticleTranslational andrology and urology2021
Clinicopathological characteristics and survival outcomes for testicular choriocarcinoma: a population-based study.
Article in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Comparative Molecular and Genetic Landscape of Gonadal Germ Cell Tumors: Insights from Testicular and Ovarian Neoplasms.Cancers · 2026Review
- Pulmonary metastasis risk and overall survival score in choriocarcinoma: a novel nomogram-based risk assessment system.Translational cancer research · 2025Article
- Comparative analysis of testicular and nontesticular choriocarcinoma: a population-based study.Annals of medicine and surgery (2012) · 2024Article
- Variations in germ cell tumor histology by age and implications for cancer-specific survival among pediatric and adult males: A population-based study.Urologic oncology · 2024Article
- A decade in focus: mixed germ cell tumors with choriocarcinoma components.Annals of medicine and surgery (2012) · 2023Article
- Risk analysis of subsequent therapies after first-line chemotherapy in advanced testicular cancer patients.Journal of the Chinese Medical Association : JCMA · 2023Article
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Abstract
backgroundDue to the scarcity of cases of testicular choriocarcinoma (CC), its clinicopathological characteristics and prognosis have not been well summarized. Consequently, we conducted this population-based case-control study to characterize the features of testicular CC.
methodsThe SEER database was used to extract qualified data. Dichotomous variables were compared by Pearson's Chi-squared or Fisher exact test. Survival variables were compared by Kaplan-Meier analyses and log-rank tests. The univariable and multivariable Cox regression analyses were applied to figure out risk factors for overall survival (OS) and cancer-specific survival (CSS). Propensity score matching (PSM) was used to control confounding factors in the study.
resultsIn total, 788 patients with CC and 19,571 patients with seminoma were identified. Significant differences were found between two groups in terms of age (≤30 years: 65.4%
conclusionsChoriocarcinoma is exceedingly rare disease with metastases at initial diagnose and has poor survival even after treatment. Old age and advanced tumor stage indicate a poor prognosis, while surgery therapy can improve prognosis. Nevertheless, longer-term studies with larger population of patients are needed to verify their biological behavior and therapeutic efficacy.
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