ArticleTranslational andrology and urology2021
Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011-2016.
Article in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Role of urate transporters in the kidneys and intestine in uric acid homeostasis.Kidney research and clinical practice · 2026Article
- Drug-induced hyperuricemia: multi-pathway regulation, causative drugs, and individualized management strategies.Frontiers in pharmacology · 2026Review
- Baseline Risk Factors and Predictive Nomogram for Short-Term Persistent Hyperuricemia Following Laparoscopic Sleeve Gastrectomy: A Dual Center Study.Obesity surgery · 2025Article
- Association Between Dietary Intake of Omega-3 Fatty Acids and Serum Testosterone in Adult Males: Results From NHANES 2011-2016 and 2021-2023.Food science & nutrition · 2025Article
- Elevated uric acid level and metabolic syndrome in Non-Hispanic Black American adults.Journal of diabetes and metabolic disorders · 2025Article
- Potential links between serum uric acid levels and testosterone levels in adult males: a cross-sectional study.Scientific reports · 2025Article
- Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh.Endocrinology, diabetes & metabolism · 2025Article
- Association between uric acid/high-density lipoprotein cholesterol ratio and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2011-2016.BMC public health · 2025Article
- Uric acid mediates the association between testosterone and α-Klotho among males: results from the NHANES 2013-2016.International urology and nephrology · 2025Article
- Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of serum uric acid with male sexual hormones and erectile dysfunction: a bidirectional 2-sample Mendelian randomization analysis.Sexual medicine · 2024Article
- Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Uric Acid Metabolic Disorders in Pituitary-Target Gland Axis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007-2018.PloS one · 2024Article
- Decoding connections in the European population: serum uric acid, sex hormone-binding globulin, total testosterone, estradiol, and female infertility - advanced bidirectional and mediative Mendelian randomization.Frontiers in endocrinology · 2024Article
- Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study.BMJ open · 2023Article
- The Association between Serum Testosterone and Hyperuricemia in Males.Journal of clinical medicine · 2022Article
- The relationship between uric acid and total femur bone mineral density in hypertensive and non-hypertensive populations.Frontiers in endocrinology · 2022Article
- The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016.Frontiers in endocrinology · 2022Article
- Unmasking Masculinity: Biological, Behavioral, and Social Determinants of Testosterone Deficiency in U.S. Men, 2011-2023.American journal of men's healthArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US.
methodsData from the National Health and Nutrition Examination Survey 2011-2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone.
resultsWe found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: -0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: -4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: -2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over.
conclusionsSUA levels might be negatively associated with serum testosterone in adult males.
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