Evidence map›Paper›PMID 33532298›Full record

ArticleTranslational andrology and urology2021

Neutrophil-lymphocyte ratio acts as a novel diagnostic biomarker for kidney stone prevalence and number of stones passed.

Weipu Mao, Jianping Wu, Ziwei Zhang, Zhipeng Xu, Bin Xu, Ming Chen

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Article in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
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32citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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32 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Weipu MaoDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Jianping WuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Ziwei ZhangDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhipeng XuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Bin XuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Ming ChenDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluated the relationship between inflammatory biomarkers and the prevalence of kidney stones and number of stones passed.

methodsWe conducted a cross-sectional study of adult participants (≥20 years) in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2014. We calculated key inflammatory biomarkers, such as the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR). Multivariate logistic regression analysis was used to determine the effect of inflammatory biomarkers on the prevalence of kidney stones and number of stones passed.

resultsA total of 21,106 participants were included in the final study, and 1,864 patients reported a history of kidney stones (including 292 who had passed no stones, 1,462 who had passed stones 1-5 times, and 110 who had passed stones >5 times). The chi-square test showed that the NLR, MLR and SII were closely related to the occurrence of kidney stones and the number of stones passed. Multivariate logistic regression analysis showed that a high NLR (>1.72) was associated with an increased prevalence of kidney stones and number of stones passed (OR =1.18, 95% CI: 1.03-1.36, P=0.019).

conclusionsA convenient biomarker, the NLR can be used as a good predictor for the diagnosis of kidney stones and number of stones passed; these findings are worthy of further research and application in clinical practice.

Indexed as

Kidney stoneNational Health and Nutrition Examination Surveyneutrophil-lymphocyte ratioprevalencestone pass number

Identifiers

PMID33532298
PMCPMC7844488

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