ArticleQuantitative imaging in medicine and surgery2021
Imaging human skin autograft integration with optical coherence tomography.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Optical to Molecular Imaging on Human Skin: A Review.Chemical & biomedical imaging · 2026Review
- Multimodal Optical Imaging and Modulation through Smart Dura in Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- Exploring the Role of Perfusion in Skin Graft Viability on the Scalp and Lower Limb: An Analysis of Graft Bed, Margin, and Donor Skin Using Laser Speckle.Journal of clinical medicine · 2024Article
- Rapid measurement of epidermal thickness in OCT images of skin.Scientific reports · 2024Article
- 4D spectral-spatial computational photoacoustic dermoscopy.Photoacoustics · 2023Article
- Fibroblast-Generated Extracellular Matrix Guides Anastomosis during Wound Healing in an Engineered Lymphatic Skin Flap.Bioengineering (Basel, Switzerland) · 2023Article
- Integrating a pressure sensor with an OCT handheld probe to facilitate imaging of microvascular information in skin tissue beds.Biomedical optics express · 2022Article
- Review
- Semisupervised representative learning for measuring epidermal thickness in human subjects in optical coherence tomography by leveraging datasets from rodent models.Journal of biomedical optics · 2022Article
- Intraoral optical coherence tomography and angiography combined with autofluorescence for dental assessment.Biomedical optics express · 2022Article
- Multiscale confocal photoacoustic dermoscopy to evaluate skin health.Quantitative imaging in medicine and surgery · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- Advances in non-invasive biosensing measures to monitor wound healing progression.Frontiers in bioengineering and biotechnology · 2022Review
- Predicting skin graft failure on the scalp by intraoperative laser speckle analysis.Anais brasileiros de dermatologiaArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin autografting is a common clinical procedure for reconstructive surgery. Despite its widespread use, very few studies have been conducted to non-invasively evaluate and monitor the vascular and structural features of skin grafts. This study, therefore, aims to demonstrate the potential of optical coherence tomography (OCT) alongside OCT-based angiography (OCTA) to non-invasively image and monitor human skin graft health and integration over time.
methodsAn in-house-built clinical prototype OCT system was used to acquire OCT/OCTA images from patients who underwent split-thickness skin graft surgery following severe burn damage to the skin. The OCT imaging was carried out at multiple locations over multiple time points with a field of view of ~9 mm × 9 mm and a penetration depth of ~1.5 mm. In addition to obtaining high-resolution qualitative images, we also quantitatively measured and compared specific structural and vascular parameters, such as identifiable layer thickness and corresponding vascular area density and diameter.
resultsTwo patients (patient #1 and #2) were enrolled for this preliminary study. Vascular and structural features were successfully imaged and measured in the graft tissue and integration layer immediately beneath at different time points. Revascularization, healing, and integration were monitored with patient-specific details. Results of the quantitative image analysis from patient #1 indicated that integration layer thickness 16-day post-surgery was significantly less (~50%) than that of 7-day post-surgery. Additionally, with patient #2, significant growth (~20%) was seen with the vascular area density of both the graft and corresponding integration layer beneath between 6 and 14 days post-surgery.
conclusionsOur preliminary studies show that OCT/OCTA has clinical potential to image and measure numerous features of human skin graft health and integration in the days and weeks following split-thickness surgery. For the first time, we demonstrate the applicability of non-invasive imaging technology for novel clinical uses that could eventually aid in the betterment of surgical practices and clinical outcomes.
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