Evidence map›Paper›PMID 33532261›Full record

ArticleQuantitative imaging in medicine and surgery2021

The value of a shorter-delay arterial spin labeling protocol for detecting cerebrovascular impairment.

Caiyu Zhuang, Julien Poublanc, Larissa Mcketton, Lakshmikumar Venkatraghavan, Olivia Sobczyk, James Duffin, Adrian P Crawley, Joseph A Fisher, Renhua Wu, David J Mikulis

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Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Caiyu ZhuangJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
Julien PoublancJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
Larissa MckettonJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
Lakshmikumar VenkatraghavanDepartment of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Olivia SobczykJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
James DuffinDepartment of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Adrian P CrawleyJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
Joseph A FisherDepartment of Anaesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Renhua WuDepartment of Medical Imaging, the Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
David J MikulisJoint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the relationship between blood oxygen level dependent (BOLD) cerebrovascular reactivity (CVR) and cerebral blood flow (CBF) obtained from arterial spin labeling (ASL) using different post labeling delays (PLD).

methodsForty-two patients with steno-occlusive diseases and impaired CVR were divided into two groups, one scanned with a 1.5-second (1.5-s) and the other with a 2.5-second (2.5-s) PLD ASL protocol. For all patients, a region of interest (ROI) was drawn around the CVR impairment. This affected ROI was then left-right flipped across the brain midline to obtain the control ROI. For both groups, the difference in grey matter CVR between affected and control ROI was first tested to confirm significance. The average grey matter CBF of affected and control ROIs were then compared. The same analysis method was used to compare affected and control hemispheres.

resultsIn both groups of 1.5-s and 2.5-s PLD, CVR values in the affected ROI (-0.049±0.055 and -0.042±0.074%/mmHg, respectively) were significantly lower compared to that in the control ROI (0.152±0.054 and 0.152±0.053%/mmHg, respectively, P<0.0001). In the group with the 1.5-s PLD, CBF in the affected ROI (37.62±11.37 mL/100 g/min) was significantly lower compared to CBF in the control ROI (44.13±11.58 mL/100 g/min, P<0.05). However, in the group with the 2.5-s PLD, no significant differences could be seen between CBF in the affected ROI (40.50±14.82 mL/100 g/min) and CBF in the control ROI (39.68±12.49 mL/100 g/min, P=0.73). In the hemisphere-based analysis, CBF was significantly lower in the affected side than in the control side for the group with the 1.5-s PLD (P<0.05) when CVR was impaired (P<0.0001), but not for the group with the 2.5-s PLD (P=0.49).

conclusionsIn conclusion, our study reveals and highlights the value of a shorter-PLD ASL protocol, which is able to reflect CVR impairment. At the same time, we offer a better understanding of the relationship between BOLD CVR and CBF obtained from ASL.

Indexed as

Arterial spin labeling (ASL)blood oxygen level dependent cerebrovascular reactivity (BOLD CVR)post labeling delay (PLD)

Identifiers

PMID33532261
PMCPMC7779917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.