ArticleActa pharmaceutica Sinica. B2021
Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-
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Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 64 citations in OpenAlex.
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- Biological assessment of Coccinia grandis leaf and Lupeol against β-lactam resistant Klebsiella pneumoniae through integrated in-silico and in-vitro studies.Scientific reports · 2026Article
- An aptamer-based "Gate-lock-key" strategy for metal-organic framework nanozyme-catalyzed colorimetric detection of multidrug-resistant bacteria.Mikrochimica acta · 2026Article
- Pharmacophore-Based Study: An In Silico Perspective for the Identification of Potential New Delhi Metallo-β-lactamase-1 (NDM-1) Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2024Article
- New Delhi Metallo-Beta-Lactamase Inhibitors: A Systematic Scoping Review.Journal of clinical medicine · 2024Article
- Betaxolol as a Potent Inhibitor of NDM-1-PositiveInternational journal of molecular sciences · 2023Article
- Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities.RSC medicinal chemistry · 2023Review
- Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors.Molecules (Basel, Switzerland) · 2022Article
- Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans.Microbiology spectrum · 2022Article
- Towards combating antibiotic resistance by exploring the quantitative structure-activity relationship of NDM-1 inhibitors.EXCLI journal · 2022Article
- Towards the discovery of potential RdRp inhibitors for the treatment of COVID-19: structure guided virtual screening, computational ADME and molecular dynamics study.Structural chemistry · 2022Article
- Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress.Frontiers in pharmacology · 2022Article
- Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers.Frontiers in oncology · 2022Review
- β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward.Frontiers in microbiology · 2022Review
- Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.Microbiology spectrum · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Bing ZhaoState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xinhui ZhangState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Tingting YuState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Ying LiuState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xiaoling ZhangState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Yongfang YaoState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xuejian FengState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Hongmin LiuState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Dequan YuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Liying MaState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Shangshang QinState Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhengzhou University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
New Delhi metallo-
Indexed as
3-AP, 3-aminopyridine carboxaldehyde thiosemicarbazoneAcOH, acetic acidAntibiotic resistance(Boc)2O, di-tert-butyl decarbonateBoc, tert-butoxycarbonylCLSI, Clinical and Laboratory Standards Instituteconc. HCl, concentrated hydrochloric acidDMAP, 4-dimethylaminopyridineDpC, di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazoneE. coli, Escherichia coliEDTA, ethylene diamine tetraacetic acidESI, electrospray ionizationHR-MS, high-resolution mass spectraIC50, half-maximal inhibitory concentrationsInhibitorK. pneumoniae, Klebsiella pneumoniaeLQTS, long QT syndromeMBLs, metallo-β-lactamases class BMEM, meropenemMHA, Mueller-Hinton AgarMHB, Mueller-Hinton BrothMIC, minimum inhibitory concentrationNDM-1, New Delhi metallo-β-lactamase-1New Delhi metallo-β-lactamase-1PBS, phosphate-buffered salinePK, pharmacokineticRBCs, red blood cellsr.t., room temperatureSAR, structure–activity relationshipTHF, tetrahydrofuranThiosemicarbazone derivativesTLC, thin layer chromatographyTMS, tetramethylsilaneUPLC, ultra-performance liquid chromatography
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