Evidence map›Paper›PMID 33532056›Full record

ArticlePulmonary circulation

Inhaled iloprost as third add-on therapy in idiopathic pulmonary arterial hypertension.

Caio J C S Fernandes, Taysa A F da Silva, Jose L Alves, Carlos V P Jardim, Rogerio de Souza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Caio J C S FernandesPulmonary Circulation Unity, Cardiopulmonology Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-4912-021X
Taysa A F da SilvaPulmonary Circulation Unity, Cardiopulmonology Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Jose L AlvesPulmonary Circulation Unity, Cardiopulmonology Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Carlos V P JardimPulmonary Circulation Unity, Cardiopulmonology Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Rogerio de SouzaPulmonary Circulation Unity, Cardiopulmonology Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0003-2789-9143
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple combination therapy is suggested in current pulmonary arterial hypertension guidelines in case of unsatisfactory treatment with oral double combination therapy. However, there is a lack of evidence concerning some of the drug combinations currently employed. We demonstrate the clinical and hemodynamical benefits of inhaled iloprost as third add-on therapy in idiopathic pulmonary arterial hypertension.

Indexed as

hemodynamicsinhaled iloprostpulmonary arterial hypertensionsequential triple combination therapy

Identifiers

PMID33532056
PMCPMC7829527
OpenAlexW3111538835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.