ArticleInternational journal of clinical and experimental pathology2021
Clinicopathologic features and prognosis of triple-negative breast cancer in China: a retrospective cohort study of patients under 35 years old.
Article in International journal of clinical and experimental pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Poor Prognostic Clinicopathological Features of Young Women with Breast Cancer in the MF18-04 Turkish National Breast Cancer Registry Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Optimal response to tislelizumab plus chemotherapy in metastatic triple-negative breast cancer: a case report and literature review.Frontiers in oncology · 2024Article
- Value of Histogram of Gray-Scale Ultrasound Image in Differential Diagnosis of Small Triple Negative Breast Invasive Ductal Carcinoma and Fibroadenoma.Cancer management and research · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
aimTo analyze factors that affect the prognosis of triple-negative breast cancer patients under 35 years old. MATERIAL AND
methodsWe retrospectively analyzed confirmed triple-negative breast cancer cases from 2000 to 2016 in multiple institutions. A total of 105 patients were included in the study, Nineteen of them were diagnosed with age ≤ 25, and 86 of them were aged between 26 to 35.
resultThere were no statistically significant differences in clinicopathologic features and treatment choices between patients aged ≤ 25 years and those aged 26-35 years (P > 0.05). Survival analysis showed no statistically significant differences in DFS and OS between the two groups (P > 0.05). Multiple factor analysis showed that age of menarche (HR 0.697, 95% CI [0.5634, 0.8631]), pregnancy correlation (HR 2.673, 95% CI [1.1581, 6.1741]), and lymph node positivity (HR 4.915, 95% CI [2.3774, 10.1627]) were independent prognostic factors that affected patients' DFS. Independent prognostic factors that influenced OS were age of menarche (HR 0.598, 95% CI [0.462 6, 0.775]) and lymph node positivity (HR 7.751, 95% CI [2.923, 20.559]).
conclusionThere was no difference in the clinicopathological features and prognosis between women ≤ 25 and women aged 26-35 years with triple-negative breast cancer. Age of menarche, pregnancy correlation, and positive lymph nodes were independent factors affecting prognosis. The relationship between reproductive factors and prognosis in young patients with triple-negative breast cancer needs further discussion.
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33532020PMC7847486What OpenQuestion holds
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