Evidence map›Paper›PMID 33531903›Full record

ArticleInternational journal of analytical chemistry2021

Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry.

Hytham Ahmed, Abdel-Aziz Wahbi, Hatem Elmongy, Ahmad Amini, Hirsh Koyi, Eva Branden, Mohamed Abdel-Rehim

Open access · goldAbstract read
In one paragraph

Article in International journal of analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Metabolites · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hytham AhmedDepartment of Pharmaceutical Analysis, Menoufia University, Menofia Governorate, Egypt.
Abdel-Aziz WahbiDepartment of Pharmaceutical Analytical Chemistry, University of Alexandria, Alexandria 21521, Egypt.
Hatem ElmongyDepartment of Pharmaceutical Analytical Chemistry, University of Alexandria, Alexandria 21521, Egypt.
Ahmad AminiSwedish Drug Agency, Uppsala, Sweden.
Hirsh KoyiDepartment of Respiratory Medicine Gävle Hospital and Centre for Research at Uppsala University/County Council of Gävleborg, Gävle, Sweden.
Eva BrandenDepartment of Respiratory Medicine Gävle Hospital and Centre for Research at Uppsala University/County Council of Gävleborg, Gävle, Sweden.
Mohamed Abdel-RehimKarolinska Institute, Solna SE17176, Sweden.ORCID https://orcid.org/0000-0002-3862-8878
Alexandria University · EGGävle Hospital · SEKarolinska Institutet · SEMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present work, the determination of omeprazole (OME) enantiomers in oral fluid and plasma samples was carried out utilizing microextraction by packed sorbent (MEPS) and liquid chromatography-tandem mass spectrometry. A chiral column with cellulose-SB phase was used for the first time for enantiomeric separation of OME with an isocratic elution system using 0.2% ammonium hydroxide in hexane-ethanol mixture (70 : 30, v/v) as the mobile phase. OME enantiomers were determined utilizing a triple quadrupole tandem mass spectrometer in positive ion mode (ESI+) monitoring mass transitions:

Identifiers

PMID33531903
PMCPMC7837791
OpenAlexW3124182706

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.