Evidence map›Paper›PMID 33531886›Full record

ArticleEngineering in life sciences2021

A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin.

Marcin Wolański, Michał Krawiec, Paul N Schwarz, Evi Stegmann, Wolfgang Wohlleben, Anina Buchmann, Harald Gross, Michael Eitel, Pierre Koch, Alma Botas and 5 more

Open access · goldAbstract read
In one paragraph

Article in Engineering in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Genome Annotation.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Marcin WolańskiFaculty of Biotechnology University of Wrocław Wrocław Poland.ORCID https://orcid.org/0000-0003-4714-0716
Michał KrawiecFaculty of Biotechnology University of Wrocław Wrocław Poland.
Paul N SchwarzDepartment of Microbiology and Biotechnology Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen Tübingen Germany.
Evi StegmannDepartment of Microbiology and Biotechnology Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen Tübingen Germany.
Wolfgang WohllebenDepartment of Microbiology and Biotechnology Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen Tübingen Germany.
Anina BuchmannGerman Centre for Infection Research (DZIF) Partner Site Tübingen Tübingen Germany.
Harald GrossGerman Centre for Infection Research (DZIF) Partner Site Tübingen Tübingen Germany.
Michael EitelDepartment of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences University of Tübingen Tübingen Germany.
Pierre KochDepartment of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences University of Tübingen Tübingen Germany.
Alma BotasDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias Universidad de Oviedo Oviedo Spain.
Carmen MéndezDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias Universidad de Oviedo Oviedo Spain.
Luz Elena NúñezEntreChem S.L. Oviedo Spain.
Francisco MorísEntreChem S.L. Oviedo Spain.
Jesus CortésEntreChem S.L. Oviedo Spain.
Jolanta Zakrzewska-CzerwińskaFaculty of Biotechnology University of Wrocław Wrocław Poland.
German Center for Infection Research · DEEntreChem (Spain) · ESUniversity of Tübingen · DEUniversity of Wrocław · PLUniversidad de Oviedo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brasilicardin A (BraA) is a promising immunosuppressive compound produced naturally by the pathogenic bacterium

Indexed as

Amycolatopsis japonicumfluorescence thermal shiftheterologous expressionNocardia terpenicasecondary metabolite gene cluster

Identifiers

PMID33531886
PMCPMC7837296
OpenAlexW3094763231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.