Trial reportJournal of interventional cardiology2021
Use of Pre- and Intensified Postprocedural Physiotherapy in Patients with Symptomatic Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Study (the 4P-TAVR Study).
Trial report in Journal of interventional cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Comprehensive geriatric assessment, and related interventions, to improve outcomes for older patients undergoing transcatheter aortic valve implantation (TAVI): a systematic review.European geriatric medicine · 2024Pooled it
- Exercise-based cardiac rehabilitation for adults after heart valve surgery.The Cochrane database of systematic reviews · 2021Pooled it
- Prehabilitation Before Cardiac Surgery and Structural Heart Interventions: An Umbrella Review of Pooled Evidence.Journal of clinical medicine · 2026Review
- Effect of Comprehensive Outpatient Cardiac Rehabilitation on All-Cause Mortality After Transcatheter Aortic Valve Implantation.Circulation reports · 2026Article
- Enhanced recovery mitigates sodium-glucose cotransporter-2 inhibitors associated mobility decline in valve surgery patients.Frontiers in cardiovascular medicine · 2026Article
- Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Exercise rehabilitation for patients undergoing interventional treatment for heart valve disease: a scoping review and evidence summary.BMC nursing · 2025Article
- Nursing Care Across the Clinical Continuum of TAVI: A Systematic Review of Multidisciplinary Roles.Journal of clinical medicine · 2025Review
- Periprocedural care for frail older patients with aortic stenosis undergoing transcatheter aortic valve replacement.International journal of cardiology. Heart & vasculature · 2025Review
- Pre-procedural nursing home length of stay and outcomes of transcatheter aortic valve replacement.Journal of the American Geriatrics Society · 2024Article
- Prehabilitation Interventions for Cardiac Surgery to Prevent Postoperative Pulmonary Complications: Systematic Review and Meta-Analysis.Iranian journal of public health · 2024Review
- Effect of preoperative inspiratory muscle training on postoperative outcomes in patients undergoing cardiac surgery: A systematic review and meta-analysis.World journal of clinical cases · 2023Article
- Inspiratory Muscle and Functional Performance of Patients Entering Cardiac Rehabilitation after Cardiac Valve Replacement.Journal of cardiovascular development and disease · 2023Article
- Impact of cardiac rehabilitation on pre- and post-operative transcatheter aortic valve replacement prognoses.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysiotherapy prior to open-heart surgery lowers the rate of pneumonia and length of the hospital stay. Pneumonia is a major contributor to short-term mortality following transcatheter aortic valve replacement (TAVR). Hence, we hypothesized that pre- and intensified postprocedural physiotherapy in patients undergoing TAVR might impact the net functional and clinical outcome. METHODS AND
resultsThe 4P-TAVR study was a prospective, monocentric, randomized trial. The study was designed to compare the efficacy and safety of intensified periprocedural physiotherapy including inspiratory muscle training versus standard postprocedural physiotherapy. Patients were randomized in a 1 : 1 fashion. 108 patients were included and followed up for 90 days after TAVR. While patients in group A (control group: 50 patients, age: 81.7 ± 5.0 years, 52% male) did not receive physiotherapy prior to TAVR, group B (intervention group: 58 patients, age: 82.2 ± 5.82 years, 47% male) participated in intensive physiotherapy. Compared to the control group, patients in the interventional group showed a lower incidence of postinterventional pneumonia (10 [20.0%] vs. 3 [5.1%],
conclusionIntensified physiotherapy is safe and has positive effects on clinical outcomes up to 90 days after TAVR but has no impact on the primary combined endpoint of mortality and rehospitalization. Longer follow-up, a multicenter design, and a higher number of subjects are needed to confirm these preliminary results. This trial is registered with DRKS00017239.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.