Evidence map›Paper›PMID 33531734›Full record

ArticleBuilding and environment2021

Investigation of potential aerosol transmission and infectivity of SARS-CoV-2 through central ventilation systems.

Leonard F Pease, Na Wang, Timothy I Salsbury, Ronald M Underhill, Julia E Flaherty, Alex Vlachokostas, Gourihar Kulkarni, Daniel P James

Open access · greenAbstract read
In one paragraph

Article in Building and environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 89 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Leonard F Pease902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Na Wang902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Timothy I Salsbury902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Ronald M Underhill902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Julia E Flaherty902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Alex Vlachokostas902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Gourihar Kulkarni902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Daniel P James902 Battelle Boulevard, P.O. Box 999, MSIN K9-89, Pacific Northwest National Laboratory (PNNL), Richland, WA, 99352, USA.
Battelle · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has raised concern of viral spread within buildings. Although near-field transmission and infectious spread within individual rooms are well studied, the impact of aerosolized spread of SARS-CoV-2 via air handling systems within multiroom buildings remains unexplored. This study evaluates the concentrations and probabilities of infection for both building interior and exterior exposure sources using a well-mixed model in a multiroom building served by a central air handling system (without packaged terminal air conditioning). In particular, we compare the influence of filtration, air change rates, and the fraction of outdoor air. When the air supplied to the rooms comprises both outdoor air and recirculated air, we find filtration lowers the concentration and probability of infection the most in connected rooms. We find that increasing the air change rate removes virus from the source room faster but also increases the rate of exposure in connected rooms. Therefore, slower air change rates reduce infectivity in connected rooms at shorter durations. We further find that increasing the fraction of virus-free outdoor air is helpful, unless outdoor air is infective in which case pathogen exposure inside persists for hours after a short-term release. Increasing the outdoor air to 33% or the filter to MERV-13 decreases the infectivity in the connected rooms by 19% or 93% respectively, relative to a MERV-8 filter with 9% outdoor air based on 100 quanta/h of 5 μm droplets, a breathing rate of 0.48 m

Indexed as

ACH, air changes per hourAHU, air handling unitAirborne transmissionCOVID-19Indoor air qualityMERV, minimum efficiency reporting valueMultizone buildingsWell-mixedWells-Riley

Identifiers

PMID33531734
PMCPMC7844370
OpenAlexW3126148813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.