Evidence map›Paper›PMID 33531632›Full record

Observational studyEuropean journal of clinical nutrition2021

Low adherence to CKD-specific dietary recommendations associates with impaired kidney function, dyslipidemia, and inflammation.

Nadine Kaesler, Seema Baid-Agrawal, Sabine Grams, Jennifer Nadal, Matthias Schmid, Markus P Schneider, Kai-Uwe Eckardt, Jürgen Floege, Manuela M Bergmann, Georg Schlieper and 1 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07473713 (Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07473713 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia: a Dose-finding Randomized Controlled Trial

TypeinterventionalSponsorTufts Medical CenterRan2026 to 2028Enrolled60ConditionsOsteopeniaArmsveverimer daily, veverimer every other day, Placebo
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Behavioural Determinants of Dietary Self-Management in Chronic Kidney Disease: A Theory-Informed Analysis to Inform Dietetic Interventions.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Review
  6. Review
  7. Article
  8. A Qualitative Study to Investigate the Nutrition Perspectives and Experiences of Veterans with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Nadine KaeslerDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Seema Baid-AgrawalDepartment of Nephrology and Transplant Center, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-8192-1079
Sabine GramsGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Jennifer NadalInstitute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.
Matthias SchmidInstitute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.
Markus P SchneiderDepartment of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Kai-Uwe EckardtDepartment of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Jürgen FloegeDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Manuela M Bergmann *German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.ORCID http://orcid.org/0000-0001-5064-227X
Georg Schlieper *Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Turgay Saritas *Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany. tsaritas@ukaachen.de.ORCID http://orcid.org/0000-0002-6691-9218
RWTH Aachen University · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Institute of Human Nutrition · DEUniversity Hospital Bonn · DESahlgrenska University Hospital · SEUniversitätsklinikum Aachen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesA diet following chronic kidney disease (CKD)-specific recommendations is considered essential for optimal management of patients with CKD. However, data on the adherence to these recommendations and its implications for health-relevant biomarkers are lacking. The objectives were to estimate adherence to CKD-specific dietary recommendations, to identify characteristics and lifestyle variables associated with poor adherence, and to investigate the relationship of adherence with biomarkers.

methodsIn this cross-sectional analysis, average dietary intake was estimated in 3193 participants with moderately severe CKD enrolled into the observational multicenter German CKD study using a food frequency questionnaire. A CKD diet score was developed to assess adherence to CKD-specific dietary recommendations based on intake of sodium, potassium, fiber, protein, sugar, and cholesterol. The associations of dietary adherence with characteristics, lifestyle variables, and biomarker levels were determined.

resultsLogistic regression analysis revealed younger age, higher body mass index, male gender, lower educational attainment, various lifestyle variables (cigarette smoking, infrequent alcohol consumption, low physical activity), and lower estimated glomerular filtrate rate associated with lower adherence to dietary recommendations. Low adherence to dietary recommendations was further associated with dyslipidemia, higher uric acid, and C-reactive protein levels. Associations between low dietary adherence and biomarkers were mostly driven by low intake of fiber and potassium, and high intake of sugar and cholesterol.

conclusionsThis study revealed differential characteristics and biomarkers associated with lower adherence to CKD-specific dietary recommendations. Promotion of CKD-specific dietary recommendations may help to mitigate the adverse prognosis in CKD patients.

Indexed as

DyslipidemiasRenal Insufficiency, ChronicCross-Sectional StudiesDietHumansInflammationKidneyMale

Identifiers

PMID33531632
PMCPMC8416654
OpenAlexW3126489239

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.