Evidence map›Paper›PMID 33531552›Full record

ArticleScientific reports2021

Cerebrum, liver, and muscle regulatory networks uncover maternal nutrition effects in developmental programming of beef cattle during early pregnancy.

Wellison J S Diniz, Matthew S Crouse, Robert A Cushman, Kyle J McLean, Joel S Caton, Carl R Dahlen, Lawrence P Reynolds, Alison K Ward

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 50 citations in OpenAlex.

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  7. Dietary Fermentation withInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wellison J S DinizDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA. w.dasilvadiniz@ndsu.edu.
Matthew S CrouseUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Robert A CushmanUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Kyle J McLeanDepartment of Animal Science, University of Tennessee, Knoxville, TN, USA.
Joel S CatonDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA.
Carl R DahlenDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA.
Lawrence P ReynoldsDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA.
Alison K WardDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, USA.
North Dakota State University · USRoman L. Hruska U.S. Meat Animal Research Center · USUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular basis underlying fetal programming in response to maternal nutrition remains unclear. Herein, we investigated the regulatory relationships between genes in fetal cerebrum, liver, and muscle tissues to shed light on the putative mechanisms that underlie the effects of early maternal nutrient restriction on bovine developmental programming. To this end, cerebrum, liver, and muscle gene expression were measured with RNA-Seq in 14 fetuses collected on day 50 of gestation from dams fed a diet initiated at breeding to either achieve 60% (RES, n = 7) or 100% (CON, n = 7) of energy requirements. To build a tissue-to-tissue gene network, we prioritized tissue-specific genes, transcription factors, and differentially expressed genes. Furthermore, we built condition-specific networks to identify differentially co-expressed or connected genes. Nutrient restriction led to differential tissue regulation between the treatments. Myogenic factors differentially regulated by ZBTB33 and ZNF131 may negatively affect myogenesis. Additionally, nutrient-sensing pathways, such as mTOR and PI3K/Akt, were affected by gene expression changes in response to nutrient restriction. By unveiling the network properties, we identified major regulators driving gene expression. However, further research is still needed to determine the impact of early maternal nutrition and strategic supplementation on pre- and post-natal performance.

Indexed as

Animal Nutritional Physiological PhenomenaFetal DevelopmentPrenatal Nutritional Physiological PhenomenaAnimalsCattleFemaleFetusNutritional StatusPregnancy

Identifiers

PMID33531552
PMCPMC7854659
OpenAlexW3126459017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.