ArticleNature communications2021
Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 94 citations in OpenAlex.
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- Synthetic Polymers for Drug, Gene, and Vaccine Delivery.Polymer science & technology (Washington, D.C.) · 2025Review
- Toward Quantitative End-Group Fidelity in the Synthesis of High Molecular Weight Polysarcosine.ACS macro letters · 2025Article
- Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization onACS central science · 2025Article
- Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis.Nature protocols · 2025Review
- Helical peptide structure improves conductivity and stability of solid electrolytes.Nature materials · 2024Article
- Nanocomposites of Poly(Polymers · 2024Article
- Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia.Bioactive materials · 2024Article
- Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease.Science advances · 2024Article
- A nanoscale MOF-based heterogeneous catalytic system for the polymerization of N-carboxyanhydrides enables direct routes toward both polypeptides and related hybrid materials.Nature communications · 2023Article
- Biodegradable Polymers and Polymer Composites with Antibacterial Properties.International journal of molecular sciences · 2023Review
- Memory Effect in Thermoresponsive Proline-based Polymers.Angewandte Chemie (International ed. in English) · 2022Article
- Solvent Gaming Chemistry to Control the Quality of Halide Perovskite Thin Films for Photovoltaics.ACS central science · 2022Article
- Article
- Open-air synthesis of oligo(ethylene glycol)-functionalized polypeptides from non-purifiedBiomaterials science · 2021Article
- Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions.Research (Washington, D.C.) · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) enriched the toolbox to prepare well-defined polypeptide materials. Herein we report the use of crown ether (CE) to catalyze the polymerization of NCA initiated by conventional primary amine initiators in solvents with low polarity and low hydrogen-bonding ability. The cyclic structure of the CE played a crucial role in the catalysis, with 18-crown-6 enabling the fastest polymerization kinetics. The fast polymerization kinetics outpaced common side reactions, enabling the preparation of well-defined polypeptides using an α-helical macroinitiator. Experimental results as well as the simulation methods suggested that CE changed the binding geometry between NCA and propagating amino chain-end, which promoted the molecular interactions and lowered the activation energy for ring-opening reactions of NCAs. This work not only provides an efficient strategy to prepare well-defined polypeptides with functionalized C-termini, but also guides the design of catalysts for NCA polymerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.