Evidence map›Paper›PMID 33531416›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Coordinated Prefrontal State Transition Leads Extinction of Reward-Seeking Behaviors.

Eleonora Russo, Tianyang Ma, Rainer Spanagel, Daniel Durstewitz, Hazem Toutounji, Georg Köhr

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Reconfiguration of Behavioral Signals in the Anterior Cingulate Cortex Based on Emotional State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Activity Subspaces in Medial Prefrontal Cortex Distinguish States of the World.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Eleonora RussoDepartment of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany eleonora.russo@zi-mannheim.de hazem.toutounji@nottingham.ac.uk.ORCID 0000-0002-6215-6305
Tianyang MaPhysiology of Neural Networks, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Rainer SpanagelInstitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.ORCID 0000-0003-2151-4521
Daniel DurstewitzDepartment of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.ORCID 0000-0002-9340-3786
Hazem ToutounjiDepartment of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany eleonora.russo@zi-mannheim.de hazem.toutounji@nottingham.ac.uk.ORCID 0000-0002-2655-3071
Georg KöhrPhysiology of Neural Networks, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.ORCID 0000-0001-6768-3545
Heidelberg University · DESIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extinction learning suppresses conditioned reward responses and is thus fundamental to adapt to changing environmental demands and to control excessive reward seeking. The medial prefrontal cortex (mPFC) monitors and controls conditioned reward responses. Abrupt transitions in mPFC activity anticipate changes in conditioned responses to altered contingencies. It remains, however, unknown whether such transitions are driven by the extinction of old behavioral strategies or by the acquisition of new competing ones. Using

Indexed as

RewardAnimalsBehavior, AnimalConditioning, OperantExtinction, PsychologicalLearningMaleNeuronsPrefrontal CortexRatsRats, Wistaralcoholattractor statesbehavioral modelchange-point analysisextinction learningprelimbic cortex

Identifiers

PMID33531416
PMCPMC7984585
OpenAlexW3128291447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.