Evidence map›Paper›PMID 33531406›Full record

ArticlemSystems2021

A High-Throughput Method for Identifying Novel Genes That Influence Metabolic Pathways Reveals New Iron and Heme Regulation in Pseudomonas aeruginosa.

David G Glanville, Caroline Mullineaux-Sanders, Christopher J Corcoran, Brian T Burger, Saheed Imam, Timothy J Donohue, Andrew T Ulijasz

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Carbapenem-resistantFrontiers in pharmacology · 2025
    Article
  7. Article
  8. Article
  9. Applications of the Whole-Cell System in the Efficient Biosynthesis of Heme.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

David G Glanville *Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.
Caroline Mullineaux-Sanders *MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College, London, United Kingdom.
Christopher J CorcoranDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.
Brian T BurgerGreat Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, Wisconsin, USA.
Saheed ImamGreat Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, Wisconsin, USA.
Timothy J DonohueGreat Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-8738-2467
Andrew T UlijaszDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA aulijasz@luc.edu.ORCID https://orcid.org/0000-0003-0739-1297
Loyola University Chicago · USUniversity of Wisconsin–Madison · USImperial College London · GB

Funding

A Regulatory Cascade that Controls Pneumococcal Capsule BiosynthesisR01AI135060 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI ULIJASZ, ANDREW T · 2019 to 2023
$2.3M
NIAID NIH HHS R01 AI135060
6 · The paper itself

Abstract

Heme is an essential metabolite for most life on earth. Bacterial pathogens almost universally require iron to infect a host, often acquiring this nutrient in the form of heme. The Gram-negative pathogen

Indexed as

biosensorFlowSeqhemeheme biosynthesisheme transportinfectionironmetabolismMet-SeqPseudomonas aeruginosaTn-seqtransposon sequencing

Identifiers

PMID33531406
PMCPMC7857532
OpenAlexW3128960184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.