Evidence map›Paper›PMID 33531400›Full record

ArticlemBio2021

Sirtuin 3 Downregulation in

Lorissa J Smulan, Nuria Martinez, Michael C Kiritsy, Chido Kativhu, Kelly Cavallo, Christopher M Sassetti, Amit Singhal, Heinz G Remold, Hardy Kornfeld

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Effect of Estrogen on Sirt1 Signaling in Human Macrophages.International journal of molecular sciences · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. eLife · 2024
    Article
  12. Article
  13. Article
  14. Virulence · 2023
    Article
  15. Review
  16. Review
  17. microLife · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lorissa J SmulanDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Nuria MartinezDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Michael C KiritsyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Chido KativhuDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Kelly CavalloDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Christopher M SassettiDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Amit SinghalInfectious Disease Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Heinz G RemoldDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hardy KornfeldDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA Hardy.Kornfeld@umassmed.edu.ORCID 0000-0002-8970-7306
University of Massachusetts Chan Medical School · USAgency for Science, Technology and Research · SGBrigham and Women's Hospital · US

Funding

Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Impact of Diabetes and Hyperlipidemia on Host DefenseR01HL081149 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY · 2006 to 2019
$5.3M
Sirtuins and Host Metabolism in TB Pathogenesis and TreatmentR01HL153162 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY, SINGHAL, AMIT · 2021 to 2024
$2.5M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Determinants of Tuberculosis SeverityR01HL127384 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY · 2016 to 2019
$2.2M
NHLBI NIH HHS R01 HL081149NHLBI NIH HHS R01 HL127384NHLBI NIH HHS R01 HL153162NIAID NIH HHS P01 AI132130NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCellular ReprogrammingMacrophagesMaleMiceMice, Inbred C57BLMitochondriaMycobacterium tuberculosisReactive Oxygen SpeciesSirtuin 3Toll-Like Receptor 2Toll-Like Receptor 4Reactive Oxygen SpeciesSirtuin 3Tlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4cell deathmacrophagesmitochondrial metabolismMycobacterium tuberculosissirtuin

Identifiers

PMID33531400
PMCPMC7858060
OpenAlexW3128419955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.