Evidence map›Paper›PMID 33531375›Full record

ArticleCancer research2021

Fragmentation of Small-Cell Lung Cancer Regulatory States in Heterotypic Microenvironments.

Dylan L Schaff, Shambhavi Singh, Kee-Beom Kim, Matthew D Sutcliffe, Kwon-Sik Park, Kevin A Janes

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. High-throughput single-сell sequencing in cancer research.Signal transduction and targeted therapy · 2022
    Review
  4. Review
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dylan L Schaff *Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-3367-9270
Shambhavi Singh *Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-6961-2289
Kee-Beom KimDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia.
Matthew D SutcliffeDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-2139-6732
Kwon-Sik ParkDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia.ORCID 0000-0003-3346-9086
Kevin A JanesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia. kjanes@virginia.edu.
University of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
An Integrated Systems Approach for Incompletely Penetrant Onco-phenotypes.U01CA215794 · NCI · UNIVERSITY OF VIRGINIA · PI JANES, KEVIN A · 2017 to 2021
$2.4M
Targeting BCAT1 and branched-chain amino acid metabolism for the detection and prevention of SCLCU01CA224293 · NCI · UNIVERSITY OF VIRGINIA · PI PARK, KWON-SIK · 2018 to 2022
$2.2M
(PQB4) Stochastic Profiling of Functional Single-Cell States Within Solid TumorsR01CA194470 · NCI · UNIVERSITY OF VIRGINIA · PI JANES, KEVIN A · 2015 to 2018
$1.8M
(PQ4A) Metabolic Plasticity of Pre-Malignant Cells During Tumor ProgressionR01CA194461 · NCI · UNIVERSITY OF VIRGINIA · PI PARK, KWON-SIK · 2015 to 2018
$1.6M
Interdisciplinary Training in Systems & Biomolecular Data ScienceT32GM145443 · NIGMS · UNIVERSITY OF VIRGINIA · PI Kevin A Janes, Jason Papin · 2022 to 2026
$1.5M
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA194461NCI NIH HHS R01 CA194470NCI NIH HHS U01 CA215794NCI NIH HHS U01 CA224293NIGMS NIH HHS T32 GM145443
6 · The paper itself

Abstract

Small-cell lung cancers derive from pulmonary neuroendocrine cells, which have stem-like properties to reprogram into other cell types upon lung injury. It is difficult to uncouple transcriptional plasticity of these transformed cells from genetic changes that evolve in primary tumors or secondary metastases. Profiling of single cells is also problematic if the required sample dissociation activates injury-like signaling and reprogramming. Here we defined cell-state heterogeneities

Indexed as

Lung NeoplasmsSmall Cell Lung CarcinomaAnimalsFemaleHumansLungMiceNeoplasm Recurrence, LocalTumor Microenvironment

Identifiers

PMID33531375
PMCPMC8137564
OpenAlexW3126182388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.