ArticleIEEE transactions on bio-medical engineering2021
Mapping Cell Viability Quantitatively and Independently From Cell Density in 3D Gels Noninvasively.
Article in IEEE transactions on bio-medical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
objectiveIn biomanufacturing there is a need for quantitative methods to map cell viability and density inside 3D bioreactors to assess health and proliferation over time. Recently, noninvasive MRI readouts of cell density have been achieved. However, the ratio of live to dead cells was not varied. Herein we present an approach for measuring the viability of cells embedded in a hydrogel independently from cell density to map cell number and health.
methodsIndependent quantification of cell viability and density was achieved by calibrating the
resultsUsing this method, the limits of detection (LODs) of total cell density and viable cell density were found to be 3.88 ×10
conclusionThis mapping technique provides a noninvasive means of visualizing cell viability and number density within optically opaque bioreactors. SIGNIFICANCE: We anticipate that such nondestructive readouts will provide valuable feedback for monitoring and controlling cell populations in bioreactors.
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