Observational studyCritical care (London, England)2021
The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study.
Observational study in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Intermittent and Continuous Subglottic Secretion Drainage in Preventing the Risk of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Control Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial.Antimicrobial resistance and infection control · 2025Trial
- Application of double-sleeve endotracheal tube in infection control for icu patients: a randomized controlled trial.Head & face medicine · 2025Trial
- Alterations of the host-lung microbiome metasystem in systemic inflammatory response syndrome is associated with secondary pneumonia.Cell reports. Medicine · 2026Article
- Comparative analysis of ventilator-associated pneumonia and ventilator-associated event surveillance systems: a retrospective observational study.Journal of Korean biological nursing science · 2026Article
- Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.Pathogens (Basel, Switzerland) · 2026Article
- Perpetual observational study of the clinical and microbiological epidemiology of ventilator-associated pneumonia in Europe.Critical care (London, England) · 2026Observational
- Development of ventilator associated pneumonia prevention knowledge and attitudes scale.BMC nursing · 2026Article
- Reduced incidence of ventilator-associated pneumonia (VAP) at a tertiary care center due to enhanced compliance with evidence-based bundle care practices through structured training programs for ICU healthcare workers: a pilot study.GMS hygiene and infection control · 2026Article
- Metagenome-assembled complete genome ofMicrobiology resource announcements · 2025Article
- Communication with Mechanically Ventilated Patients: Nurses' Perspectives and Practice.Nursing reports (Pavia, Italy) · 2025Article
- Real-time detection of respiratory circuit events in mechanical ventilation using deep learning.NPJ digital medicine · 2025Article
- Epidemiology of ventilator associated events in intubated patients: a multicenter observational study.BMC infectious diseases · 2025Observational
- Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients.Cell reports. Medicine · 2025Article
- Incidence and clinical outcomes of ventilator-associated events in Russian tertiary care settings: an analysis of electronic health records.BMC research notes · 2025Article
- Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation.Intensive care medicine · 2025Article
- Associations Between Elevated Rates of Depression, Anxiety, and PTSD Among ICU Survivors and Increased Mortality and Readmissions.Brain and behavior · 2025Article
- Targeted temperature management in patients with acute basilar artery occlusion after successful recanalization.Frontiers in neurology · 2025Article
- Critical Care Nurses' Knowledge on Prevention of Ventilator-associated Pneumonia: A Cross-sectional Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Enhancing ICU Outcomes Through Intelligent Monitoring Systems: A Comparative Study on Ventilator-Associated Events.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundVentilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced traditional VAP surveillance and is now widely used in the USA. However, the adoption outside the USA is limited. This study aims to describe the epidemiology and clinical outcomes of VAEs in China, based on a prospectively maintained registry.
methodsAn observational study was conducted using an ICU-HAI registry in west China. Patients that were admitted to ICUs and underwent mechanical ventilation (MV) between April 1, 2015, and December 31, 2018, were included. The characteristics and outcomes were compared between patients with and without VAEs. The rates of all VAEs dependent on different ICUs were calculated, and the pathogen distribution of patients with possible VAP (PVAP) was described.
resultsA total of 20,769 ICU patients received MV, accounting for 21,723 episodes of mechanical ventilators and 112,697 ventilator-days. In all, we identified 1882 episodes of ventilator-associated condition (VAC) events (16.7 per 1000 ventilator-days), 721 episodes of infection-related ventilator-associated complications (IVAC) events (6.4 per 1000 ventilator-days), and 185 episodes of PVAP events (1.64 per 1000 ventilator-days). The rates of VAC varied across ICUs with the highest incidence in surgical ICUs (23.72 per 1000 ventilator-days). The median time from the start of ventilation to the onset of the first VAC, IVAC, and PVAP was 5 (3-8), 5 (3-9), and 6 (4-13) days, respectively. The median length of hospital stays was 28.00 (17.00-43.00), 30.00 (19.00-44.00), and 30.00 (21.00-46.00) days for the three VAE tiers, which were all longer than that of patients without VAEs (16.00 [12.00-23.00]). The hospital mortality among patients with VAEs was more than three times of those with non-VAEs.
conclusionsVAE was common in ICU patients with ≥ 4 ventilator days. All tiers of VAEs were highly correlated with poor clinical outcomes, including longer ICU and hospital stays and increased risk of mortality. These findings highlight the importance of VAE surveillance and the development of new strategies to prevent VAEs.
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