Evidence map›Paper›PMID 33531059›Full record

Trial reportBMC research notes2021

Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study.

Thomas Olsen, Bente Øvrebø, Cheryl Turner, Nasser E Bastani, Helga Refsum, Kathrine J Vinknes

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02647970 (Stearoyl-CoA Desaturase and Energy Metabolism in Humans), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02647970 nacompletednot on this map

Stearoyl-CoA Desaturase and Energy Metabolism in Humans

TypeinterventionalSponsorUniversity of OsloRan2016 to 2016Enrolled14ConditionsHealthy, ObesityArmsPUFA-Cys/Met diet, SFA+Cys/Met diet
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolite Comparison between Spleen-Deficiency and Healthy Children.Evidence-based complementary and alternative medicine : eCAM · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Thomas OlsenDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway. thomas.olsen@medisin.uio.no.ORCID http://orcid.org/0000-0003-1805-5221
Bente ØvrebøDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.
Cheryl TurnerDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
Nasser E BastaniDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.
Helga RefsumDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.
Kathrine J VinknesDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.
University of Oslo · NOUniversity of Oxford · GB

Funding

Norges Forskningsråd 239948
6 · The paper itself

Abstract

objectiveIn this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cys

resultsThe diet groups consisted of five women and two men, aged 20-38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cys

trial registrationClinicalTrials.gov: NCT02647970, registration date: January 6

Indexed as

CysteineFatty AcidsAdultAmino AcidsDietary FatsFatty Acids, UnsaturatedFemaleGlucose Tolerance TestHumansLactic AcidMaleMethioninePilot ProjectsPyruvic AcidYoung AdultAmino AcidsCysteineDietary FatsFatty AcidsFatty Acids, UnsaturatedLactic AcidMethioninePyruvic AcidCysteine restrictionFatty acidsMethionine restrictionOral glucose tolerancePyruvateSCD

Identifiers

PMID33531059
PMCPMC7852127
OpenAlexW3127578432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.