ArticleBMC plant biology2021
Genome-wide identification and functional analysis of the ERF2 gene family in response to disease resistance against Stemphylium lycopersici in tomato.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 64 citations in OpenAlex.
- GmERF109 Positively Enhances Soybean Resistance to Phytophthora sojae by Transcriptionally Activating GmG4DT-Like to Promote Glyceollin I Accumulation.Molecular plant pathology · 2026Article
- TaWRKY33 Positively Regulates TaERF1-A, Thereby Activating TaP5CSPlant, cell & environment · 2026Article
- Expression profiles of transcription factors and aquaporins suggest putative roles in rubber biosynthesis regulation and drought stress adaptation in guayule.Scientific reports · 2026Article
- An ERF Gene DcERF3 of Dendrobium catenatum Improves Salt Tolerance in Arabidopsis.Molecular biotechnology · 2026Article
- Genome-wide identification of the AP2/ERF gene family and its alternative splicing to reveal their expression profiles in different tissues of Rosa roxburghii.BMC plant biology · 2026Article
- Genome- and Transcriptome-Wide Characterization of AP2/ERF Transcription Factor Superfamily Reveals Their Relevance inPlants (Basel, Switzerland) · 2026Article
- Comprehensive characterization of the genes in AP2/ERF family and their involvement in salt-alkali stress response duringFrontiers in plant science · 2026Article
- The AP2/ERF Gene Family in Camphor Tree: Structure, Evolution, and Transcriptional Response to Epicoccum Infection.Plants (Basel, Switzerland) · 2025Article
- Identification of Leaf Rust-Related Gene Signature in Wheat (Triticum Aestivum L.) Using High-Throughput Sequencing, Network Analysis, and Machine Learning Algorithms.Rice (New York, N.Y.) · 2025Article
- Jasmonic acid-mediated cell wall biosynthesis pathway involved in pepper (Capsicum annuum) defense response to Ralstonia solanacearum.BMC plant biology · 2025Article
- Isolation of the AP2/ERF transcription factor CaERF14 in pepper and functional characterization under salinity and dehydration stress.Scientific reports · 2025Article
- Overexpression of the GmERF071 gene confers resistance to soybean cyst nematode in soybean.The plant genome · 2025Article
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- Transcriptomic Profiling Reveals Regulatory Pathways of Tomato in Resistance to Verticillium Wilt Triggered by VdR3e.Plants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification and Expression Analysis of TONNEAU1 Recruited Motif (TRM) Gene Family in Tomato.International journal of molecular sciences · 2025Article
- Genome-Wide Identification and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cloning of the DlERF10 gene from Diospyros lotus L. and cold tolerance analysis of the DlERF10 gene in transgenic tobacco plants.PloS one · 2025Article
- DNA Methylation Is Crucial for 1-Methylcyclopropene Delaying Postharvest Ripening and Senescence of Tomato Fruit.International journal of molecular sciences · 2024Article
- Master Regulatory Transcription Factors in β-Aminobutyric Acid-Induced Resistance (BABA-IR): A Perspective on Phytohormone Biosynthesis and Signaling inInternational journal of molecular sciences · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
backgroundAPETALA2/ethylene responsive factor (AP2/ERF) transcription factors are a plant-specific family of transcription factors and one of the largest families of transcription factors. Ethylene response factors (ERF) regulate plant growth, development, and responses to biotic and abiotic stress. In a previous study, the ERF2 gene was significantly upregulated in both resistant and susceptible tomato cultivars in response to Stemphylium lycopersici. The main purpose of this study was to systematically analyze the ERF family and to explore the mechanism of ERF2 in tomato plants resisting pathogen infection by the Virus-induced Gene Silencing technique.
resultsIn this experiment, 134 ERF genes were explored and subjected to bioinformatic analysis and divided into twelve groups. The spatiotemporal expression characteristics of ERF transcription factor gene family in tomato were diverse. Combined with RNA-seq, we found that the expression of 18 ERF transcription factors increased after inoculation with S. lycopersici. In ERF2-silenced plants, the susceptible phenotype was observed after inoculation with S. lycopersici. The hypersensitive response and ROS production were decreased in the ERF2-silenced plants. Physiological analyses showed that the superoxide dismutase, peroxidase and catalase activities were lower in ERF2-silenced plants than in control plants, and the SA and JA contents were lower in ERF2-silenced plants than in control plants after inoculation with S. lycopersici. Furthermore, the results indicated that ERF2 may directly or indirectly regulate Pto, PR1b1 and PR-P2 expression and enhance tomato resistance.
conclusionsIn this study, we identified and analyzed members of the tomato ERF family by bioinformatics methods and classified, described and analyzed these genes. Subsequently, we used VIGS technology to significantly reduce the expression of ERF2 in tomatoes. The results showed that ERF2 had a positive effect on tomato resistance to S. lycopersici. Interestingly, ERF2 played a key role in multiple SA, JA and ROS signaling pathways to confer resistance to invasion by S. lycopersici. In addition, ERF2 may directly or indirectly regulate Pto, PR1b1 and PR-P2 expression and enhance tomato resistance to S. lycopersici. In summary, this study provides gene resources for breeding for disease resistance in tomato.
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