Evidence map›Paper›PMID 33530942›Full record

Trial reportBMC anesthesiology2021

Comparison of the in-vivo effect of two tranexamic acid doses on fibrinolysis parameters in adults undergoing valvular cardiac surgery with cardiopulmonary bypass - a pilot investigation.

Zhen-Feng Zhou, Wen Zhai, Li-Na Yu, Kai Sun, Li-Hong Sun, Xiu-Fang Xing, Min Yan

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05994989 (The Effect of Two Different Tranexamic Acid Dose Regimens on Intraoperative and Postoperative Bleeding in Coronary Artery Bypass Surgery), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05994989 completednot on this mapstarted 2023, after this paper: background citation

The Effect of Two Different Tranexamic Acid Dose Regimens on Intraoperative and Postoperative Bleeding in Coronary Artery Bypass Surgery

TypeobservationalSponsorSaglik Bilimleri Universitesi Gazi Yasargil Training and Research HospitalRan2023 to 2024Enrolled90ConditionsPostoperative Hemorrhage
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zhen-Feng ZhouDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Wen ZhaiDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Li-Na YuDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Kai SunDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Li-Hong SunDepartment of Anesthesiology, Women's Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Xiu-Fang XingDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China.
Min YanDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, China. zryanmin@zju.edu.cn.ORCID 0000-0002-1355-1261
Second Affiliated Hospital of Zhejiang University · CNAffiliated Hospital of Hangzhou Normal University · CNWomen's Hospital, School of Medicine, Zhejiang University · CNZhejiang Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe blood saving efficacy of TXA in cardiac surgery has been proved in several studies, but TXA dosing regimens were varied in those studies. Therefore, we performed this study to investigate if there is a dose dependent in-vivo effect of TXA on fibrinolysis parameters by measurement of fibrinolysis markers in adults undergoing cardiac surgery with CPB.

methodsA double-blind, randomized, controlled prospective trial was conducted from February 11, 2017 to May 05, 2017. Thirty patients undergoing cardiac valve surgery were identified and randomly divided into a placebo group, low-dose group and high-dose group by 1: 1: 1. Fibrinolysis parameters were measured by plasma levels of D-Dimers, plasminogen activator inhibitor-1 (PAI-1), thrombin activatable fibrinolysis inhibitor (TAFI), plasmin-antiplasmin complex (PAP), tissue plasminogen activator (tPA) and thrombomodulin (TM). Those proteins were measured at five different sample times: preoperatively before the TXA injection (T

resultsCompared with the control group, the level of the D-Dimers decreased in the low-dose and high-dose groups when the patients arrived at the ICU and on the first postoperative morning. Over time, the concentrations of PAI-1, TAFI, and TM, but not PAP and tPA, showed significant differences between the three groups (P <  0.05). Compared with the placebo group, the plasma concentrations of PAI-1 and TAFI decreased significantly at the T3 and T4 (P <  0.05); TAFI concentrations also decreased at the T5 in low-dose group (P < 0.05). Compared with the low-dose group, the concentration of TM increased significantly at the T4 in high-dose group.

conclusionsThe in-vivo effect of low dose TXA is equivalent to high dose TXA on fibrinolysis parameters in adults with a low bleeding risk undergoing valvular cardiac surgery with cardiopulmonary bypass, and a low dose TXA regimen might be equivalent to high dose TXA for those patients.

trial registrationChiCTR-IPR-17010303 , Principal investigator: Zhen-feng ZHOU, Date of registration: January 1, 2017.

Indexed as

AdultAntifibrinolytic AgentsCardiac Surgical ProceduresCardiopulmonary BypassDouble-Blind MethodFibrinolysisHeart ValvesHumansPilot ProjectsProspective StudiesTranexamic AcidTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidCardiac surgerFibrinolysisTissue plasminogen activatorTranexamic acid

Identifiers

PMID33530942
PMCPMC7852217
OpenAlexW3127205693

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.