Evidence map›Paper›PMID 33530831›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2.

Visesha Kakarla, Naoki Kaneko, May Nour, Kasra Khatibi, Fanny Elahi, David S Liebeskind, Jason D Hinman

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Visesha KakarlaSchool of Medicine, University of California San Diego, San Diego, CA, USA.ORCID 0000-0002-7681-7223
Naoki KanekoDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
May NourDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kasra KhatibiDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Fanny ElahiMemory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
David S LiebeskindDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jason D HinmanDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0872-5044
University of California, Los Angeles · USUniversity of California San Diego · USUniversity of California, San Francisco · US

Funding

Shear Stress and Endothelial Pathophysiology in Intracranial AtherosclerosisR01NS112799 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HINMAN, JASON D, LIEBESKIND, DAVID SIGMUND · 2020 to 2025
$3.8M
CSRD VA IK2 CX002180NINDS NIH HHS R01 NS112799
6 · The paper itself

Abstract

Cerebrovascular events have emerged as a central feature of the clinical syndrome associated with Sars-CoV-2 infection. This increase in infection-related strokes is marked by atypical presentations including stroke in younger patients and a high rate of hemorrhagic transformation after ischemia. A variety of pathogenic mechanisms may underlie this connection. Efforts to identify synergism in the pathophysiology underlying stroke and Sars-CoV-2 infection can inform the understanding of both conditions in novel ways. In this review, the molecular cascades connected to Sars-CoV-2 infection are placed in the context of the cerebral vasculature and in relationship to pathways known to be associated with stroke. Cytokine-mediated promotion of systemic hypercoagulability is suggested while direct Sars-CoV-2 infection of cerebral endothelial cells may also contribute. Endotheliopathy resulting from direct Sars-CoV-2 infection of the cerebral vasculature can modulate ACE2/AT

Indexed as

Angiotensin-Converting Enzyme 2Blood-Brain BarrierCerebrovascular DisordersComplement ActivationCOVID-19HumansProto-Oncogene MasRenin-Angiotensin SystemSpike Glycoprotein, CoronavirusStrokeVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Proto-Oncogene MasSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2endotheliainfectioninflammationSars-CoV-2stroke

Identifiers

PMID33530831
PMCPMC8142132
OpenAlexW3127898368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.