ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2021
Externalizing Risk Pathways for Adolescent Substance Use and Its Developmental Onset: A Canadian Birth Cohort Study: Trajectoires de comportements extériorisés et le risque pour l'initiation et l'usage de substances des adolescents : Une étude de cohorte de naissance canadienne.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.Biological psychiatry global open science · 2026Article
- Predictors of Follow-Up Engagement in an Adolescent Alcohol Longitudinal Cohort.Journal of studies on alcohol and drugs · 2026Article
- Familial risk factors required to predict earlier adolescent substance use in youth with externalizing disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Do different types of potentially traumatic events hold different relationships with substance use in adolescence?Journal of child & adolescent trauma · 2026Article
- Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors.Research on child and adolescent psychopathology · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Sex differences in Cingulo-Opercular activation during risky decision-making in youth with externalizing disorders.Psychiatry research. Neuroimaging · 2025Article
- A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [Alcohol, clinical & experimental research · 2025Article
- Cannabis Use and Subsequent Cigarette Discontinuation Among U.S. Adults in the Population Assessment of Tobacco and Health Study, Waves 1-5.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Increased risk of smoking and pain in individuals with intermittent explosive disorder in the All of Us dataset.Frontiers in psychiatry · 2025Article
- Substance use patterns in 9 to 13-year-olds: Longitudinal findings from the Adolescent Brain Cognitive Development (ABCD) study.Drug and alcohol dependence reports · 2022Article
- Gene-environment interplay in externalizing behavior from childhood through adulthood.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Development and Evaluation of the Global Appraisal of Individual Needs Quick Version 4 (GAIN-Q4) for ASAM Dimension Ratings and Placement Recommendations for Adolescents and Adults.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
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Abstract
objectiveOnly a minority of drug and alcohol users develops a substance use disorder. Previous studies suggest that this differential vulnerability commonly reflects a developmental trajectory characterized by diverse externalizing behaviors. In this study, we examined the relation between child and adolescent externalizing behaviors and adolescent substance use in a prospectively followed Canadian birth cohort, accounting for the temporal sequence of a wide variety of contributing factors.
methodsTwo hundred and forty-two adolescents followed since birth (date range: 1996 to 2012) were assessed on externalizing behavior (age 17 months to 16 years), alcohol and cannabis use at age 16, age of alcohol use onset, family history of substance use problems, family functioning (age 11 to 15), sensation seeking (age 16), prenatal substance exposure, socioeconomic status (age 1 to 9), and sex.
resultsAge of alcohol use onset was predicted by a family history of substance use problems, externalizing traits from ages 6 to 10 and 11 to 16, sensation seeking at age 16, prenatal alcohol and tobacco exposure and family functioning at ages 11 to 15. High frequencies of alcohol and cannabis use at age 16 were both predicted by externalizing traits from ages 11 to 16, a family history of substance use problems and sensation seeking after controlling for other individual, environmental and familial variables. The association between familial substance use problems and substance use during adolescence was partially mediated by externalizing traits from age 11 to 16.
conclusionsThe present findings provide prospective evidence for a developmental risk pathway for adolescent substance use, potentially identifying those who could benefit from early interventions.
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