Evidence map›Paper›PMID 33530644›Full record

ArticleMolecules (Basel, Switzerland)2021

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia.

Gert Warncke, Georg Singer, Jana Windhaber, Lukas Schabl, Elena Friehs, Wolfram Miekisch, Peter Gierschner, Ingeborg Klymiuk, Ernst Eber, Katarina Zeder and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Gert WarnckeDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.ORCID 0000-0002-4611-9934
Georg SingerDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.ORCID 0000-0003-4770-3144
Jana WindhaberDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Lukas SchablDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Elena FriehsDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Wolfram MiekischDepartment of Anesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, 18057 Rostock, Germany.ORCID 0000-0003-1619-0315
Peter GierschnerDepartment of Anesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, 18057 Rostock, Germany.ORCID 0000-0001-6201-3411
Ingeborg KlymiukCore Facility Molecular Biology, Center for Medical Research, Medical University of Graz, 8036 Graz, Austria.
Ernst EberDepartment of Paediatrics and Adolescent Medicine, Division of Paediatric Pulmonology and Allergology, Medical University of Graz, 8036 Graz, Austria.
Katarina ZederDepartment of Paediatrics and Adolescent Medicine, Division of Paediatric Pulmonology and Allergology, Medical University of Graz, 8036 Graz, Austria.
Andreas PflegerDepartment of Paediatrics and Adolescent Medicine, Division of Paediatric Pulmonology and Allergology, Medical University of Graz, 8036 Graz, Austria.
Beate ObermüllerDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Holger TillDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Christoph CastellaniDepartment of Paediatric and Adolescent Surgery, Medical University Graz, 8036 Graz, Austria.
Medical University of Graz · ATUniversity of Rostock · DE

Funding

City of Graz NAinVITA - Gesellschaft zur Foerderung der Gesundheit unserer Kinder NAVerein fuer Kinderchirurgie an der Medizinischen Universitaet Graz NA
6 · The paper itself

Abstract

The aim of this study was to analyze the exhaled volatile organic compounds (VOCs) profile, airway microbiome, lung function and exercise performance in congenital diaphragmatic hernia (CDH) patients compared to healthy age and sex-matched controls. A total of nine patients (median age 9 years, range 6-13 years) treated for CDH were included. Exhaled VOCs were measured by GC-MS. Airway microbiome was determined from deep induced sputum by 16S rRNA gene sequencing. Patients underwent conventional spirometry and exhausting bicycle spiroergometry. The exhaled VOC profile showed significantly higher levels of cyclohexane and significantly lower levels of acetone and 2-methylbutane in CDH patients. Microbiome analysis revealed no significant differences for alpha-diversity, beta-diversity and LefSe analysis. CDH patients had significantly lower relative abundances of

Indexed as

AcetoneAdolescentBacteriaChildDNA, BacterialDNA, RibosomalExerciseFemaleHernias, Diaphragmatic, CongenitalHerniorrhaphyHumansMaleMicrobiotaPentanesPhylogenyRNA, Ribosomal, 16SAcetoneDNA, BacterialDNA, RibosomalisopentanePentanesRNA, Ribosomal, 16SVolatile Organic CompoundsCDHmicrobiomeoutcomespiroergometryVOCs

Identifiers

PMID33530644
PMCPMC7865878
OpenAlexW3125061897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.