ReviewInternational journal of molecular sciences2021
Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Time-Varying Association of Acute and Post-Acute COVID-19 With Gestational Diabetes Mellitus.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Advances in Oral Drug Delivery Systems for Natural Polyunsaturated Fatty Acids: Enhancing Bioavailability and Therapeutic Potential.Pharmaceutics · 2025Review
- The prevalence of symptomatic COVID-19 infection among pregnant women and its relationship with pregnancy outcomes: a retrospective review of the medical records in North East Iran.BMC pregnancy and childbirth · 2025Article
- Vitamin D Deficiency and Risk of Gestational Diabetes Mellitus in Western Countries: A Scoping Review.Nutrients · 2025Article
- The dual challenge of diabesity: pathophysiology, management, and future directions.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The association of dietary total antioxidant capacity and gestational diabetes: a prospective cohort study from the Mothers and their children's health (MATCH).Nutrition & diabetes · 2024Article
- Assessing lipoxin-mediated inflammatory responses in the second trimester of pregnancy among women with obesity: A comprehensive analysis.Turkish journal of obstetrics and gynecology · 2023Article
- Intervention Effects of Physical Activity on Type 2 Diabetic Patients Potentially Infected with COVID-19.Medicina (Kaunas, Lithuania) · 2023Review
- The Role of Diet during Pregnancy in Protecting against Gestational Diabetes Mellitus in a Population with Mediterranean Dietary Habits: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Adherence to the Mediterranean Diet Association with Serum Inflammatory Factors Stress Oxidative and Appetite in COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Gestational diabetes mellitus in the COVID-19 pandemic: A retrospective study from Hangzhou, China.Journal of diabetes · 2022Article
- COVID-19 and Gestational Diabetes: The Role of Nutrition and Pharmacological Intervention in Preventing Adverse Outcomes.Nutrients · 2022Review
- Review
- Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?Nutrients · 2022Review
- The prevention of gestational diabetes mellitus (The role of lifestyle): a meta-analysis.Diabetology & metabolic syndrome · 2022Review
- Periconceptional Mediterranean diet during pregnancy on children's health.Journal of preventive medicine and hygiene · 2022Review
- Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0.International journal of molecular sciences · 2022Review
- Influence of Nutritional Intakes in Japan and the United States on COVID-19 Infection.Nutrients · 2022Article
- Analysis of Risk Factors for the Development of Gestational Diabetes Mellitus in a Group of Romanian Patients.Journal of diabetes research · 2022Article
- Adipokines as potential biomarkers for type 2 diabetes mellitus in cats.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.
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