Evidence map›Paper›PMID 33530466›Full record

ReviewInternational journal of molecular sciences2021

Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair.

Hsuan Peng, Kazuhiro Shindo, Renée R Donahue, Ahmed Abdel-Latif

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  5. Article
  6. Mass Customized Outlook for Regenerative Heart Failure Care.International journal of molecular sciences · 2021
    Review
  7. Contribution of Cardiac CD34⁺ Stromal Cells to Post-Myocardial Infarction Repair in Middle-Aged Rats.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hsuan PengGill Heart and Vascular Institute and Division of Cardiovascular Medicine, University of Kentucky and The Lexington VA Medical Center, Lexington, KY 40508, USA.
Kazuhiro ShindoGill Heart and Vascular Institute and Division of Cardiovascular Medicine, University of Kentucky and The Lexington VA Medical Center, Lexington, KY 40508, USA.ORCID 0000-0003-3734-8134
Renée R DonahueGill Heart and Vascular Institute and Division of Cardiovascular Medicine, University of Kentucky and The Lexington VA Medical Center, Lexington, KY 40508, USA.
Ahmed Abdel-LatifGill Heart and Vascular Institute and Division of Cardiovascular Medicine, University of Kentucky and The Lexington VA Medical Center, Lexington, KY 40508, USA.

Funding

NIH HHS R01 HL124266
6 · The paper itself

Abstract

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

Indexed as

Cell- and Tissue-Based TherapyAnimalsClinical Trials as TopicDisease Models, AnimalHeart DiseasesHumansImmunomodulationMesenchymal Stem CellsMyoblasts, CardiacRegenerationStem CellsStem Cell TransplantationTreatment OutcomeWound Healingheart failureinflammationmesenchymal stem cellsmyocardial infarctionstem cell therapy

Identifiers

PMID33530466
PMCPMC7865339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.