Evidence map›Paper›PMID 33530399›Full record

ArticleNutrients2021

Green Salad Intake Is Associated with Improved Oral Cancer Survival and Lower Soluble CD44 Levels.

Elizabeth Bradford Bell, Isildinha M Reis, Erin R Cohen, Turki Almuhaimid, Drew H Smith, Faisal Alotaibi, Claudia Gordon, Carmen Gomez-Fernandez, W Jarrard Goodwin, Elizabeth J Franzmann

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Diet and Oral Squamous Cell Carcinoma: A Scoping Review.International journal of environmental research and public health · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Elizabeth Bradford BellDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Isildinha M ReisSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Erin R CohenDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-3417-2762
Turki AlmuhaimidDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Drew H SmithDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-9671-542X
Faisal AlotaibiDepartment of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj 16245, Saudi Arabia.
Claudia GordonDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Carmen Gomez-FernandezDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
W Jarrard GoodwinDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Elizabeth J FranzmannDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
University of Miami · USPrince Sattam Bin Abdulaziz University · SA

Funding

Salivary Soluble Markers in Head and Neck CancerR01CA118584 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FRANZMANN, ELIZABETH J · 2007 to 2010
$1.3M
Salivary Soluble CD44: A Molecular Marker for HNSCCR03CA107828 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FRANZMANN, ELIZABETH JANE · 2004 to 2005
$152k
Bankhead-Coley 10BG-02Bankhead-Coley 4BB-20NCI NIH HHS R01CA118584NCI NIH HHS RO3CA107828
6 · The paper itself

Abstract

Deficiencies in fruit and vegetable intake have been associated with oral cancer (oral cavity and oropharyngeal). Salivary rinses contain measurable biomarkers including soluble CD44 (solCD44) and total protein, which are known markers of oral cancer risk. This study investigates the effect of nutritional factors on solCD44 and protein levels to evaluate oral cancer risk and survival. We evaluated solCD44 and protein levels from 150 patients with oral and oropharyngeal squamous cell carcinoma and 150 frequency-matched controls. We subsequently characterized the effect of food group consumption and these biomarkers on progression-free survival (PFS) and overall survival (OS). Patients reported eating fewer servings of salad (

Indexed as

SaladsAgedBiomarkers, TumorCase-Control StudiesDietary ProteinsFemaleFruitHead and Neck NeoplasmsHumansHyaluronan ReceptorsLife StyleMaleMiddle AgedMouth NeoplasmsPrognosisProgression-Free SurvivalBiomarkers, TumorCD44 protein, humanDietary ProteinsHyaluronan Receptorscancer outcomesdiethead and neck cancernutritionsalivary biomarkers

Identifiers

PMID33530399
PMCPMC7911809
OpenAlexW3123922442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.